Reprogramming Therapeutics: IPS Cell Prospects for Neurodegenerative Disease

Overview

Journal Neuron

Publisher Cell Press

Specialty Neurology

Date 2009 Feb 17

PMID 19217371

Citations 15

Authors

Asa Abeliovich

Claudia A Doege

Affiliations

Soon will be listed here.

Abstract

The recent description of somatic cell reprogramming to an embryonic stem (ES) cell-like phenotype, termed induced pluripotent stem (iPS) cell technology, presents an exciting potential venue toward cell-based therapeutics and disease models for neurodegenerative disorders. Two recent studies (Dimos et al. and Ebert et al.) describe the initial characterization of neurodegenerative disease patient-derived iPS cell cultures as proof of concept for the utility of this technology.

Citing Articles

Genotyping, generation and proteomic profiling of the first human autosomal dominant osteopetrosis type II-specific induced pluripotent stem cells.

Ou M, Li C, Tang D, Xue W, Xu Y, Zhu P Stem Cell Res Ther. 2019; 10(1):251.

PMID: 31412925 PMC: 6693165. DOI: 10.1186/s13287-019-1369-8.

Direct conversion of mouse astrocytes into neural progenitor cells and specific lineages of neurons.

Ma K, Deng X, Xia X, Fan Z, Qi X, Wang Y Transl Neurodegener. 2018; 7:29.

PMID: 30410751 PMC: 6217767. DOI: 10.1186/s40035-018-0132-x.

Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele.

Oni E, Halikere A, Li G, Toro-Ramos A, Swerdel M, Verpeut J Sci Rep. 2016; 6:34341.

PMID: 27698409 PMC: 5048107. DOI: 10.1038/srep34341.

Induced Pluripotent Stem Cells as a Novel Tool in Psychiatric Research.

Kim S, Kim M, Oh D, Lee S, Kim B Psychiatry Investig. 2016; 13(1):8-17.

PMID: 26766942 PMC: 4701689. DOI: 10.4306/pi.2016.13.1.8.

Nutraceuticals against Neurodegeneration: A Mechanistic Insight.

Dadhania V, Trivedi P, Vikram A, Tripathi D Curr Neuropharmacol. 2016; 14(6):627-40.

PMID: 26725888 PMC: 4981739. DOI: 10.2174/1570159x14666160104142223.

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