Hepatic Stem/progenitor Cells and Stem-cell Transplantation for the Treatment of Liver Disease

Overview

Journal J Gastroenterol

Specialty Gastroenterology

Date 2009 Feb 14

PMID 19214659

Citations 26

Authors

Sei Kakinuma

Hiromitsu Nakauchi

Mamoru Watanabe

Affiliations

Soon will be listed here.

Abstract

Allogeneic liver transplantation is still the only effective treatment available to patients with liver failure. However, because there is a serious shortage of liver donors, an alternative therapeutic approach is needed. Transplantation of mature hepatocytes has been evaluated in clinical trials, but the long-term efficacy remains unclear and the paucity of donor cells limits this strategy. Stem-cell transplantation is a more promising alternative approach. Several studies have provided information about the mechanism underlying the proliferation and differentiation of hepatic stem/progenitor cells. Moreover, in experimental models of liver disease, transplantation of hepatic stem/progenitor cells or hepatocyte-like cells derived from multipotent stem cells led to donor cell-mediated repopulation of the liver and improved survival rates. However, before stem-cell transplantation can be applied in the clinic to treat liver failure in humans, it will be necessary to overcome several difficulties associated with the technique.

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