Molecular Imaging in Atherosclerosis, Thrombosis, and Vascular Inflammation

Overview

Journal Arterioscler Thromb Vasc Biol

Date 2009 Feb 14

PMID 19213945

Citations 46

Authors

Robin P Choudhury

Edward A Fisher

Affiliations

Soon will be listed here.

Abstract

Appreciation of the molecular and cellular processes of atherosclerosis, thrombosis, and vascular inflammation has identified new targets for imaging. The common goals of molecular imaging approaches are to accelerate and refine diagnosis, provide insights that reveal disease diversity, guide specific therapies, and monitor the effects of those therapies. Here we undertake a comparative analysis of imaging modalities that have been used in this disease area. We consider the elements of contrast agents, emphasizing how an understanding of the biology of atherosclerosis and its complications can inform optimal design. We address the potential and limitations of current contrast approaches in respect of translation to clinically usable agents and speculate on future applications.

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References

Lindner J, Song J, Christiansen J, Klibanov A, Xu F, Ley K . Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin. Circulation. 2001; 104(17):2107-12. DOI: 10.1161/hc4201.097061. View

Weller G, Villanueva F, Tom E, Wagner W . Targeted ultrasound contrast agents: in vitro assessment of endothelial dysfunction and multi-targeting to ICAM-1 and sialyl Lewisx. Biotechnol Bioeng. 2005; 92(6):780-8. DOI: 10.1002/bit.20625. View

Trivedi R, U-King-Im J, Graves M, Cross J, Horsley J, Goddard M . In vivo detection of macrophages in human carotid atheroma: temporal dependence of ultrasmall superparamagnetic particles of iron oxide-enhanced MRI. Stroke. 2004; 35(7):1631-5. DOI: 10.1161/01.STR.0000131268.50418.b7. View

Choudhury R, Fuster V, Badimon J, Fisher E, Fayad Z . MRI and characterization of atherosclerotic plaque: emerging applications and molecular imaging. Arterioscler Thromb Vasc Biol. 2002; 22(7):1065-74. DOI: 10.1161/01.atv.0000019735.54479.2f. View

Larose E, Yeghiazarians Y, Libby P, Yucel E, Aikawa M, Kacher D . Characterization of human atherosclerotic plaques by intravascular magnetic resonance imaging. Circulation. 2005; 112(15):2324-31. DOI: 10.1161/CIRCULATIONAHA.105.538942. View

Brown M, Boles K, van der Merwe P, Kumar V, Mathew P, Barclay A . 2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48. J Exp Med. 1998; 188(11):2083-90. PMC: 2212392. DOI: 10.1084/jem.188.11.2083. View

Frias J, Williams K, Fisher E, Fayad Z . Recombinant HDL-like nanoparticles: a specific contrast agent for MRI of atherosclerotic plaques. J Am Chem Soc. 2004; 126(50):16316-7. DOI: 10.1021/ja044911a. View

Chen J, Pham W, Weissleder R, Bogdanov Jr A . Human myeloperoxidase: a potential target for molecular MR imaging in atherosclerosis. Magn Reson Med. 2004; 52(5):1021-8. DOI: 10.1002/mrm.20270. View

Yun M, Yeh D, Araujo L, Jang S, Newberg A, Alavi A . F-18 FDG uptake in the large arteries: a new observation. Clin Nucl Med. 2001; 26(4):314-9. DOI: 10.1097/00003072-200104000-00007. View

10.

Villanueva F, Jankowski R, Klibanov S, Pina M, Alber S, Watkins S . Microbubbles targeted to intercellular adhesion molecule-1 bind to activated coronary artery endothelial cells. Circulation. 1998; 98(1):1-5. DOI: 10.1161/01.cir.98.1.1. View

11.

Galis Z, Sukhova G, Lark M, Libby P . Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest. 1994; 94(6):2493-503. PMC: 330083. DOI: 10.1172/JCI117619. View

12.

Leong-Poi H, Christiansen J, Klibanov A, Kaul S, Lindner J . Noninvasive assessment of angiogenesis by ultrasound and microbubbles targeted to alpha(v)-integrins. Circulation. 2003; 107(3):455-60. DOI: 10.1161/01.cir.0000044916.05919.8b. View

13.

Shapiro E, Skrtic S, Sharer K, Hill J, Dunbar C, Koretsky A . MRI detection of single particles for cellular imaging. Proc Natl Acad Sci U S A. 2004; 101(30):10901-6. PMC: 503717. DOI: 10.1073/pnas.0403918101. View

14.

Sarai M, Hartung D, Petrov A, Zhou J, Narula N, Hofstra L . Broad and specific caspase inhibitor-induced acute repression of apoptosis in atherosclerotic lesions evaluated by radiolabeled annexin A5 imaging. J Am Coll Cardiol. 2007; 50(24):2305-12. DOI: 10.1016/j.jacc.2007.08.044. View

15.

Tsimikas S, Palinski W, Halpern S, Yeung D, Curtiss L, Witztum J . Radiolabeled MDA2, an oxidation-specific, monoclonal antibody, identifies native atherosclerotic lesions in vivo. J Nucl Cardiol. 1999; 6(1 Pt 1):41-53. DOI: 10.1016/s1071-3581(99)90064-8. View

16.

Schwarz M, Meade G, Stoll P, Ylanne J, Bassler N, Chen Y . Conformation-specific blockade of the integrin GPIIb/IIIa: a novel antiplatelet strategy that selectively targets activated platelets. Circ Res. 2006; 99(1):25-33. DOI: 10.1161/01.RES.0000232317.84122.0c. View

17.

Briley-Saebo K, Shaw P, Mulder W, Choi S, Vucic E, Aguinaldo J . Targeted molecular probes for imaging atherosclerotic lesions with magnetic resonance using antibodies that recognize oxidation-specific epitopes. Circulation. 2008; 117(25):3206-15. PMC: 4492476. DOI: 10.1161/CIRCULATIONAHA.107.757120. View

18.

Gerszten R, Garcia-Zepeda E, Lim Y, Yoshida M, Ding H, Gimbrone Jr M . MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature. 1999; 398(6729):718-23. DOI: 10.1038/19546. View

19.

Winter P, Neubauer A, Caruthers S, Harris T, Robertson J, Williams T . Endothelial alpha(v)beta3 integrin-targeted fumagillin nanoparticles inhibit angiogenesis in atherosclerosis. Arterioscler Thromb Vasc Biol. 2006; 26(9):2103-9. DOI: 10.1161/01.ATV.0000235724.11299.76. View

20.

Weissleder R, Moore A, Mahmood U, Bhorade R, Benveniste H, Chiocca E . In vivo magnetic resonance imaging of transgene expression. Nat Med. 2000; 6(3):351-5. DOI: 10.1038/73219. View