The Bi-Directional Relationship Between Periodontal Disease and Hyperlipidemia

Overview

Journal Eur J Dent

Publisher Thieme

Specialty Dentistry

Date 2009 Feb 13

PMID 19212526

Citations 28

Authors

Ozlem Fentoglu

F Yesim Bozkurt

Affiliations

Soon will be listed here.

Abstract

It has been proposed for several decades that infections may be responsible for the accelerated development of atherosclerosis. The initiation of the atherosclerotic plaque is ascribed to focal accumulation of lipids. This explains the importance of plasma lipids in the development of atherosclerosis. Recent reports point towards a possible association between periodontal disease and increased risk for cardiovascular disease. Thus, periodontitis and cardiovascular disease may share common risk factors, and association between periodontitis and coronary heart disease may be due to the elevated levels of plasma lipids. Epidemiological and clinical studies have also suggested that there is a relationship between periodontal disease and impaired lipid metabolism. In this review, we summarized the potential link mechanisms in the association between periodontal infection and serum lipids.

Citing Articles

Exploration of oral microbiota alteration and AI-driven non-invasive hyperspectral imaging for CAD prediction.

Li Z, Yang X, Zhang D, Shi X, Lei L, Zhou F BMC Cardiovasc Disord. 2025; 25(1):102.

PMID: 39955509 PMC: 11829377. DOI: 10.1186/s12872-025-04555-5.

Retrospective analysis of characteristics of patients presenting to the emergency room following dental treatment.

Hwang J, Ryu J, Moon C, Lee J J Korean Assoc Oral Maxillofac Surg. 2025; 50(6):326-332.

PMID: 39743329 PMC: 11701507. DOI: 10.5125/jkaoms.2024.50.6.326.

Curcumin administration mitigates periodontitis-induced tissue damage in hypercholesterolemic rats: a natural preventive approach.

Antona M, Ramos C, Orzuza R, Gonzalez G, Gonzalez P, Cabrera J Odontology. 2024; .

PMID: 39707059 DOI: 10.1007/s10266-024-01042-9.

Inflammation indices in association with periodontitis and cancer.

Walther K, Groger S, Vogler J, Wostmann B, Meyle J Periodontol 2000. 2024; 96(1):281-315.

PMID: 39317462 PMC: 11579835. DOI: 10.1111/prd.12612.

Relationship between Carotid Intima-Media Thickness, Periodontal Disease, and Systemic Inflammation Biomarkers in an Adult Population.

Uriza C, Roa N, Velosa-Porras J, Poveda J, Otero L, Ruiz A Biomedicines. 2024; 12(7).

PMID: 39062000 PMC: 11274352. DOI: 10.3390/biomedicines12071425.

References

de Pablo M, Ortega E, Gallego A, Alvarez C, Pancorbo P, Alvarez de Cienfuegos G . The effect of dietary fatty acid manipulation on phagocytic activity and cytokine production by peritoneal cells from Balb/c mice. J Nutr Sci Vitaminol (Tokyo). 1998; 44(1):57-67. DOI: 10.3177/jnsv.44.57. View

Nam S, Lee W, JARMOLYCH J, Lee K, Thomas W . Rapid production of advanced atherosclerosis in swine by a combination of endothelial injury and cholesterol feeding. Exp Mol Pathol. 1973; 18(3):369-79. DOI: 10.1016/0014-4800(73)90032-4. View

Krause S, Brachmann P, BRANDES C, Losche W, Hoffmann T, Gangler P . Aggregation behaviour of blood granulocytes in patients with periodontal disease. Arch Oral Biol. 1990; 35(1):75-7. DOI: 10.1016/0003-9969(90)90119-u. View

Croft K, Beilin L, VANDONGEN R, Rouse I, Masarei J . Leukocyte and platelet function and eicosanoid production in subjects with hypercholesterolaemia. Atherosclerosis. 1990; 83(2-3):101-9. DOI: 10.1016/0021-9150(90)90155-c. View

DAiuto F, Nibali L, Parkar M, Suvan J, Tonetti M . Short-term effects of intensive periodontal therapy on serum inflammatory markers and cholesterol. J Dent Res. 2005; 84(3):269-73. DOI: 10.1177/154405910508400312. View

Cutler C, Machen R, Jotwani R, Iacopino A . Heightened gingival inflammation and attachment loss in type 2 diabetics with hyperlipidemia. J Periodontol. 1999; 70(11):1313-21. DOI: 10.1902/jop.1999.70.11.1313. View

Van Lenten B, Fogelman A, Haberland M, Edwards P . The role of lipoproteins and receptor-mediated endocytosis in the transport of bacterial lipopolysaccharide. Proc Natl Acad Sci U S A. 1986; 83(8):2704-8. PMC: 323368. DOI: 10.1073/pnas.83.8.2704. View

Lopes-Virella M . Interactions between bacterial lipopolysaccharides and serum lipoproteins and their possible role in coronary heart disease. Eur Heart J. 1993; 14 Suppl K:118-24. View

Lanza-Jacoby S, Tabares A . Triglyceride kinetics, tissue lipoprotein lipase, and liver lipogenesis in septic rats. Am J Physiol. 1990; 258(4 Pt 1):E678-85. DOI: 10.1152/ajpendo.1990.258.4.E678. View

10.

Roder J, Klein M . Target-effector interaction in the natural killer cell system. IV. Modulation by cyclic nucleotides. J Immunol. 1979; 123(6):2785-90. View

11.

Cutler C, Shinedling E, Nunn M, Jotwani R, Kim B, Nares S . Association between periodontitis and hyperlipidemia: cause or effect?. J Periodontol. 2000; 70(12):1429-34. DOI: 10.1902/jop.1999.70.12.1429. View

12.

Samra J, Summers L, Frayn K . Sepsis and fat metabolism. Br J Surg. 1996; 83(9):1186-96. PMC: 11440814. View

13.

Cutler C, Kalmar J, Genco C . Pathogenic strategies of the oral anaerobe, Porphyromonas gingivalis. Trends Microbiol. 1995; 3(2):45-51. DOI: 10.1016/s0966-842x(00)88874-5. View

14.

Calder P . Fatty acids, dietary lipids and lymphocyte functions. Biochem Soc Trans. 1995; 23(2):302-9. DOI: 10.1042/bst0230302. View

15.

Listgarten M . Nature of periodontal diseases: pathogenic mechanisms. J Periodontal Res. 1987; 22(3):172-8. DOI: 10.1111/j.1600-0765.1987.tb01560.x. View

16.

Morita M, Horiuchi M, Kinoshita Y, Yamamoto T, Watanabe T . Relationship between blood triglyceride levels and periodontal status. Community Dent Health. 2004; 21(1):32-6. View

17.

Kurpad A, Khan K, Calder A, Coppack S, Frayn K, Macdonald I . Effect of noradrenaline on glycerol turnover and lipolysis in the whole body and subcutaneous adipose tissue in humans in vivo. Clin Sci (Lond). 1994; 86(2):177-84. DOI: 10.1042/cs0860177. View

18.

Mattila K, Nieminen M, Valtonen V, Rasi V, Kesaniemi Y, Syrjala S . Association between dental health and acute myocardial infarction. BMJ. 1989; 298(6676):779-81. PMC: 1836063. DOI: 10.1136/bmj.298.6676.779. View

19.

Cabana V, Siegel J, SABESIN S . Effects of the acute phase response on the concentration and density distribution of plasma lipids and apolipoproteins. J Lipid Res. 1989; 30(1):39-49. View

20.

Yla-Herttuala S . Macrophages and oxidized low density lipoproteins in the pathogenesis of atherosclerosis. Ann Med. 1991; 23(5):561-7. DOI: 10.3109/07853899109150518. View