Molecular Mechanisms of Go Signaling

Overview

Journal Neurosignals

Specialties Cell Biology
Neurology

Date 2009 Feb 13

PMID 19212138

Citations 54

Authors

Meisheng Jiang

Neil S Bajpayee

Affiliations

Soon will be listed here.

Abstract

Go is the most abundant G protein in the central nervous system, where it comprises about 1% of membrane protein in mammalian brains. It functions to couple cell surface receptors to intercellular effectors, which is a critical process for cells to receive, interpret and respond to extracellular signals. Go protein belongs to the pertussis toxin-sensitive Gi/Go subfamily of G proteins. A number of G-protein-coupled receptors transmit stimuli to intercellular effectors through Go. Go regulates several cellular effectors, including ion channels, enzymes, and even small GTPases to modulate cellular function. This review summarizes some of the advances in Go research and proposes areas to be further addressed in exploring the functional role of Go.

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