Interpreting Epidemiological Evidence in the Presence of Multiple Endpoints: an Alternative Analytic Approach Using the 9-year Follow-up of the Seychelles Child Development Study

Overview

Journal Int Arch Occup Environ Health

Specialty Environmental Health

Date 2009 Feb 12

PMID 19205720

Citations 1

Authors

Edwin van Wijngaarden

Gary J Myers

Sally W Thurston

Conrad F Shamlaye

Philip W Davidson

Affiliations

Soon will be listed here.

Abstract

Purpose: The potential for ill-informed causal inference is a major concern in published longitudinal studies evaluating impaired neurological function in children prenatally exposed to background levels of methyl mercury (MeHg). These studies evaluate a large number of developmental tests. We propose an alternative analysis strategy that reduces the number of comparisons tested in these studies.

Methods: Using data from the 9-year follow-up of 643 children in the Seychelles child development study, we grouped 18 individual endpoints into one overall ordinal outcome variable as well as by developmental domains. Subsequently, ordinal logistic regression analyses were performed.

Results: We did not find an association between prenatal MeHg exposure and developmental outcomes at 9 years of age.

Conclusion: Our proposed framework is more likely to result in a balanced interpretation of a posteriori associations. In addition, this new strategy should facilitate the use of complex epidemiological data in quantitative risk assessment.

Citing Articles

Prenatal chemical exposures and child language development.

Dzwilewski K, Schantz S J Commun Disord. 2015; 57:41-65.

PMID: 26255253 PMC: 4548902. DOI: 10.1016/j.jcomdis.2015.07.002.

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