Identification of Monoclinic Calcium Pyrophosphate Dihydrate and Hydroxyapatite in Human Sclera Using Raman Microspectroscopy

Overview

Journal Int J Exp Pathol

Publisher Wiley

Specialty Pathology

Date 2009 Feb 10

PMID 19200254

Citations 11

Authors

Ko-Hua Chen

Mei-Jane Li

Wen-Ting Cheng

Tonci Balic-Zunic

Shan-Yang Lin

Affiliations

Soon will be listed here.

Abstract

Raman microspectroscopy was first used to determine the composition of a calcified plaque located at the pterygium-excision site of a 51-year-old female patient's left nasal sclera after surgery. It was unexpectedly found that the Raman spectrum of the calcified sample at 1149, 1108, 1049, 756, 517, 376 and 352/cm was similar to the Raman spectrum of monoclinic form of calcium pyrophosphate dihydrate (CPPD) crystal, but differed from the Raman spectrum of triclinic form of CPPD. An additional peak at 958/cm was also observed in the Raman spectrum of the calcified plaque, which was identical to the characteristic peak at 958/cm of hydroxyapatite (HA). This is the first study to report the spectral biodiagnosis of both monoclinic CPPD and HA co-deposited in the calcified plaque of a patient with sclera dystrophic calcification using Raman microspectroscopy.

Citing Articles

Calcium Pyrophosphate Crystal Formation and Deposition: Where Do we Stand and What Does the Future hold?.

Sirotti S, Scanu A, Pascart T, Niessink T, Maroni P, Lombardi G Curr Rheumatol Rep. 2024; 26(10):354-365.

PMID: 39088093 PMC: 11377473. DOI: 10.1007/s11926-024-01161-w.

Sociodemographic Factors and Comorbidities Including Hyperparathyroidism Are Associated With an Increased Risk of Band Keratopathy: A Population-Based Study in Taiwan.

Jan R, Wang J, Tseng S, Chang Y Front Endocrinol (Lausanne). 2022; 13:927513.

PMID: 35784561 PMC: 9240185. DOI: 10.3389/fendo.2022.927513.

Synthesis and characterization of antibacterial drug loaded β-tricalcium phosphate powders for bone engineering applications.

Topsakal A, Ekren N, Kilic O, Oktar F, Mahirogullari M, Ozkan O J Mater Sci Mater Med. 2020; 31(2):16.

PMID: 31965360 DOI: 10.1007/s10856-019-6356-1.

Effect of reaction solvent on hydroxyapatite synthesis in sol-gel process.

Nazeer M, Yilgor E, Yagci M, Unal U, Yilgor I R Soc Open Sci. 2018; 4(12):171098.

PMID: 29308248 PMC: 5750015. DOI: 10.1098/rsos.171098.

Role of "osteogenic" cardiac fibroblasts in pathological heart calcification.

Zhan H, Suzuki T Stem Cell Investig. 2017; 4:26.

PMID: 28447041 PMC: 5388674. DOI: 10.21037/sci.2017.03.05.

References

Bernauer W, Thiel M, Kurrer M, Heiligenhaus A, Rentsch K, Schmitt A . Corneal calcification following intensified treatment with sodium hyaluronate artificial tears. Br J Ophthalmol. 2006; 90(3):285-8. PMC: 1856937. DOI: 10.1136/bjo.2005.082792. View

Chang Y, Huang C, Liu C . Frequency of linear hyperechogenicity over the basal ganglia in young infants with congenital rubella syndrome. Clin Infect Dis. 1996; 22(3):569-71. DOI: 10.1093/clinids/22.3.569. View

Steinbach L, Resnick D . Calcium pyrophosphate dihydrate crystal deposition disease: imaging perspectives. Curr Probl Diagn Radiol. 2000; 29(6):209-29. DOI: 10.1016/s0363-0188(00)90014-8. View

Yamagami T, Kawano N, Nakano H . Calcification of the cervical ligamentum flavum--case report. Neurol Med Chir (Tokyo). 2000; 40(4):234-8. DOI: 10.2176/nmc.40.234. View

Kalasinsky K, Kalasinsky V . Infrared and Raman microspectroscopy of foreign materials in tissue specimens. Spectrochim Acta A Mol Biomol Spectrosc. 2005; 61(7):1707-13. DOI: 10.1016/j.saa.2004.12.048. View

Derfus B, Kranendonk S, Camacho N, Mandel N, Kushnaryov V, Lynch K . Human osteoarthritic cartilage matrix vesicles generate both calcium pyrophosphate dihydrate and apatite in vitro. Calcif Tissue Int. 1998; 63(3):258-62. DOI: 10.1007/s002239900523. View

Caldemeyer K, Smith R . Familial hypophosphatemic rickets causing ocular calcification and optic canal narrowing. AJNR Am J Neuroradiol. 1995; 16(6):1252-4. PMC: 8337831. View

Cheng P, Pritzker K . The effect of calcium and magnesium ions on calcium pyrophosphate crystal formation in aqueous solutions. J Rheumatol. 1981; 8(5):772-82. View

Shields J, Shields C . CME review: sclerochoroidal calcification: the 2001 Harold Gifford Lecture. Retina. 2002; 22(3):251-61. DOI: 10.1097/00006982-200206000-00001. View

10.

Lin S, Chen K, Cheng W, Ho C, Wang S . Preliminary identification of Beta-carotene in the vitreous asteroid bodies by micro-Raman spectroscopy and HPLC analysis. Microsc Microanal. 2007; 13(2):128-32. DOI: 10.1017/S143192760707002X. View

11.

Garimella R, Bi X, Anderson H, Camacho N . Nature of phosphate substrate as a major determinant of mineral type formed in matrix vesicle-mediated in vitro mineralization: An FTIR imaging study. Bone. 2006; 38(6):811-7. DOI: 10.1016/j.bone.2005.11.027. View

12.

Bencardino J, Hassankhani A . Calcium pyrophosphate dihydrate crystal deposition disease. Semin Musculoskelet Radiol. 2003; 7(3):175-85. DOI: 10.1055/s-2003-43228. View

13.

Chan E, Morales D, Welsh C, McDermott M, Schwarz M . Calcium deposition with or without bone formation in the lung. Am J Respir Crit Care Med. 2002; 165(12):1654-69. DOI: 10.1164/rccm.2108054. View

14.

Besada E, Barr R, Natu A . Bilateral disk edema with unilateral macular serous fluid secondary to neurocysticercosis. Optometry. 2005; 76(4):239-49. DOI: 10.1016/s1529-1839(05)70299-2. View

15.

Hamada J, Ono W, Tamai K, Saotome K, Hoshino T . Analysis of calcium deposits in calcific periarthritis. J Rheumatol. 2001; 28(4):809-13. View

16.

Chen K, Cheng W, Li M, Lin S . Corneal calcification: chemical composition of calcified deposit. Graefes Arch Clin Exp Ophthalmol. 2005; 244(3):407-10. DOI: 10.1007/s00417-005-1191-0. View

17.

Costello J, Ryan L . Modulation of chondrocyte production of extracellular inorganic pyrophosphate. Curr Opin Rheumatol. 2004; 16(3):268-72. DOI: 10.1097/00002281-200405000-00017. View

18.

Maugars Y, Peru L, el Messaoudi B, Michaud G, Berthelot J, Prost A . Pelvic pseudotumoral calcium pyrophosphate dihydrate deposition: an ultrastructural study. J Rheumatol. 1994; 21(3):573-6. View

19.

Chen K, Cheng W, Li M, Yang D, Lin S . Calcification of senile cataractous lens determined by Fourier transform infrared (FTIR) and Raman microspectroscopies. J Microsc. 2005; 219(Pt 1):36-41. DOI: 10.1111/j.1365-2818.2005.01491.x. View

20.

Raina U, Tuli D, Arora R, Mehta D, Taneja M . Tubercular endophthalmitis simulating retinoblastoma. Am J Ophthalmol. 2000; 130(6):843-5. DOI: 10.1016/s0002-9394(00)00646-2. View