Pleiotropic Effects of Fenofibrate
Overview
Authors
Affiliations
Fenofibrate represents the most commonly used fibric acid derivative. The drug exerts its metabolic effects by modulating the expression of several genes involved in lipoprotein metabolism. In addition, numerous studies suggest that fenofibrate may also affect the progression of the atherosclerotic process by several lipid-independent mechanisms. This review considers the clinical pharmacology of fenofibrate and the current evidence on the pleiotropic effects of this fibric acid derivative.
Haptoglobin phenotype and levels in type 2 diabetes and effects of fenofibrate.
Januszewski A, Young H, Ong K, Li L, OConnell R, Lyons T J Diabetes Investig. 2024; 15(11):1663-1668.
PMID: 39171747 PMC: 11527820. DOI: 10.1111/jdi.14290.
Zhang Y, Jia X, Liu Y, Yu W, Si Y, Guo S Front Nutr. 2022; 9:971581.
PMID: 36172518 PMC: 9511108. DOI: 10.3389/fnut.2022.971581.
Frazier R, Mehta R, Cai X, Lee J, Napoli S, Craven T Kidney Int Rep. 2019; 4(1):94-102.
PMID: 30596172 PMC: 6308372. DOI: 10.1016/j.ekir.2018.09.006.
Malur P, Menezes A, DiNicolantonio J, OKeefe J, Lavie C Mo Med. 2018; 114(6):464-471.
PMID: 30228666 PMC: 6139978.
A review of time courses and predictors of lipid changes with fenofibric acid-statin combination.
Filippatos T Cardiovasc Drugs Ther. 2012; 26(3):245-55.
PMID: 22592524 PMC: 3368211. DOI: 10.1007/s10557-012-6394-0.