Hydrostatic Pressure in Articular Cartilage Tissue Engineering: from Chondrocytes to Tissue Regeneration

Overview

Journal Tissue Eng Part B Rev

Specialties Anatomy & Histology
Biotechnology

Date 2009 Feb 7

PMID 19196119

Citations 80

Authors

Benjamin D Elder

Kyriacos A Athanasiou

Affiliations

Soon will be listed here.

Abstract

Cartilage has a poor intrinsic healing response, and neither the innate healing response nor current clinical treatments can restore its function. Therefore, articular cartilage tissue engineering is a promising approach for the regeneration of damaged tissue. Because cartilage is exposed to mechanical forces during joint loading, many tissue engineering strategies use exogenous stimuli to enhance the biochemical or biomechanical properties of the engineered tissue. Hydrostatic pressure (HP) is emerging as arguably one of the most important mechanical stimuli for cartilage, although no optimal treatment has been established across all culture systems. Therefore, this review evaluates prior studies on articular cartilage involving the use of HP, with a particular emphasis on the treatments that appear promising for use in future studies. Additionally, this review addresses HP bioreactor design, chondroprotective effects of HP, the use of HP for chondrogenic differentiation, the effects of high pressures, and HP mechanotransduction.

Citing Articles

Orbital shaking conditions augment human nasoseptal cartilage formation in 3D culture.

Jovic T, Zhao F, Jia H, Doak S, Whitaker I Front Bioeng Biotechnol. 2024; 12:1360089.

PMID: 38558791 PMC: 10978724. DOI: 10.3389/fbioe.2024.1360089.

Compressive stress gradients direct mechanoregulation of anisotropic growth in the zebrafish jaw joint.

Godivier J, Lawrence E, Wang M, Hammond C, Nowlan N PLoS Comput Biol. 2024; 20(2):e1010940.

PMID: 38330044 PMC: 10880962. DOI: 10.1371/journal.pcbi.1010940.

Unraveling cartilage degeneration through synergistic effects of hydrostatic pressure and biomimetic temperature increase.

Guo Y, Stampoultzis T, Nasrollahzadeh N, Karami P, Rana V, Applegate L iScience. 2023; 26(12):108519.

PMID: 38125014 PMC: 10730382. DOI: 10.1016/j.isci.2023.108519.

Simultaneous Hydrostatic and Compressive Loading System for Mimicking the Mechanical Environment of Living Cartilage Tissue.

Chang M, Takahashi Y, Miyahira K, Omuro Y, Montagne K, Yamada R Micromachines (Basel). 2023; 14(8).

PMID: 37630168 PMC: 10456493. DOI: 10.3390/mi14081632.

Low-oxygen tension augments chondrocyte sensitivity to biomimetic thermomechanical cues in cartilage-engineered constructs.

Stampoultzis T, Guo Y, Nasrollahzadeh N, Rana V, Karami P, Pioletti D iScience. 2023; 26(8):107491.

PMID: 37599834 PMC: 10432199. DOI: 10.1016/j.isci.2023.107491.

References

Buckwalter J . Articular cartilage: injuries and potential for healing. J Orthop Sports Phys Ther. 1998; 28(4):192-202. DOI: 10.2519/jospt.1998.28.4.192. View

Wagner D, Lindsey D, Li K, Tummala P, Chandran S, Smith R . Hydrostatic pressure enhances chondrogenic differentiation of human bone marrow stromal cells in osteochondrogenic medium. Ann Biomed Eng. 2008; 36(5):813-20. DOI: 10.1007/s10439-008-9448-5. View

Waters R, Lunsford B, Perry J, Byrd R . Energy-speed relationship of walking: standard tables. J Orthop Res. 1988; 6(2):215-22. DOI: 10.1002/jor.1100060208. View

Tanck E, Van Driel W, Hagen J, Burger E, Blankevoort L, Huiskes R . Why does intermittent hydrostatic pressure enhance the mineralization process in fetal cartilage?. J Biomech. 1999; 32(2):153-61. DOI: 10.1016/s0021-9290(98)00165-1. View

Carver S, Heath C . Increasing extracellular matrix production in regenerating cartilage with intermittent physiological pressure. Biotechnol Bioeng. 1999; 62(2):166-74. View

Browning J, Walker R, Hall A, Wilkins R . Modulation of Na+ x H+ exchange by hydrostatic pressure in isolated bovine articular chondrocytes. Acta Physiol Scand. 1999; 166(1):39-45. DOI: 10.1046/j.1365-201x.1999.00534.x. View

Parkkinen J, Ikonen J, Lammi M, Laakkonen J, Tammi M, Helminen H . Effects of cyclic hydrostatic pressure on proteoglycan synthesis in cultured chondrocytes and articular cartilage explants. Arch Biochem Biophys. 1993; 300(1):458-65. DOI: 10.1006/abbi.1993.1062. View

Trindade M, Shida J, Ikenoue T, Lee M, Lin E, Yaszay B . Intermittent hydrostatic pressure inhibits matrix metalloproteinase and pro-inflammatory mediator release from human osteoarthritic chondrocytes in vitro. Osteoarthritis Cartilage. 2004; 12(9):729-35. DOI: 10.1016/j.joca.2004.05.008. View

Hall A . Differential effects of hydrostatic pressure on cation transport pathways of isolated articular chondrocytes. J Cell Physiol. 1999; 178(2):197-204. DOI: 10.1002/(SICI)1097-4652(199902)178:2<197::AID-JCP9>3.0.CO;2-3. View

10.

Carver S, Heath C . Semi-continuous perfusion system for delivering intermittent physiological pressure to regenerating cartilage. Tissue Eng. 1999; 5(1):1-11. DOI: 10.1089/ten.1999.5.1. View

11.

Mizuno S, Tateishi T, Ushida T, Glowacki J . Hydrostatic fluid pressure enhances matrix synthesis and accumulation by bovine chondrocytes in three-dimensional culture. J Cell Physiol. 2002; 193(3):319-27. DOI: 10.1002/jcp.10180. View

12.

Elder B, Athanasiou K . Synergistic and additive effects of hydrostatic pressure and growth factors on tissue formation. PLoS One. 2008; 3(6):e2341. PMC: 2394656. DOI: 10.1371/journal.pone.0002341. View

13.

Miyanishi K, Trindade M, Lindsey D, Beaupre G, Carter D, Goodman S . Dose- and time-dependent effects of cyclic hydrostatic pressure on transforming growth factor-beta3-induced chondrogenesis by adult human mesenchymal stem cells in vitro. Tissue Eng. 2006; 12(8):2253-62. DOI: 10.1089/ten.2006.12.2253. View

14.

Sironen R, Karjalainen H, Torronen K, Elo M, Kaarniranta K, Takigawa M . High pressure effects on cellular expression profile and mRNA stability. A cDNA array analysis. Biorheology. 2002; 39(1-2):111-7. View

15.

Lee M, Trindade M, Ikenoue T, Schurman D, Goodman S, Smith R . Intermittent hydrostatic pressure inhibits shear stress-induced nitric oxide release in human osteoarthritic chondrocytes in vitro. J Rheumatol. 2003; 30(2):326-8. View

16.

Scherer K, Schunke M, Sellckau R, Hassenpflug J, Kurz B . The influence of oxygen and hydrostatic pressure on articular chondrocytes and adherent bone marrow cells in vitro. Biorheology. 2004; 41(3-4):323-33. View

17.

Hansen U, Schunke M, Domm C, Ioannidis N, Hassenpflug J, Gehrke T . Combination of reduced oxygen tension and intermittent hydrostatic pressure: a useful tool in articular cartilage tissue engineering. J Biomech. 2001; 34(7):941-9. DOI: 10.1016/s0021-9290(01)00050-1. View

18.

Horowitz S, Lau Y . A function that relates protein synthetic rates to potassium activity in vivo. J Cell Physiol. 1988; 135(3):425-34. DOI: 10.1002/jcp.1041350309. View

19.

Takahashi K, Kubo T, Arai Y, Kitajima I, Takigawa M, Imanishi J . Hydrostatic pressure induces expression of interleukin 6 and tumour necrosis factor alpha mRNAs in a chondrocyte-like cell line. Ann Rheum Dis. 1998; 57(4):231-6. PMC: 1752582. DOI: 10.1136/ard.57.4.231. View

20.

Lammi M, Inkinen R, Parkkinen J, Hakkinen T, Jortikka M, Nelimarkka L . Expression of reduced amounts of structurally altered aggrecan in articular cartilage chondrocytes exposed to high hydrostatic pressure. Biochem J. 1994; 304 ( Pt 3):723-30. PMC: 1137394. DOI: 10.1042/bj3040723. View