Parasympathetic Tonic Dilatory Influences on Cerebral Vessels

Overview

Journal Auton Neurosci

Publisher Elsevier

Specialty Neurology

Date 2009 Feb 7

PMID 19195933

Citations 19

Authors

Nicholas C Boysen

Deidre Nitschke Dragon

William T Talman

Affiliations

Soon will be listed here.

Abstract

Parasympathetic nerves from the pterygopalatine ganglia may participate in development of cluster headaches, in vascular responses to hypertension and in modulation of damage due to stroke. Stimulation of the nerves elicits cerebral vasodilatation, but it is not known if the nerves tonically influence cerebrovascular tone. We hypothesized that parasympathetics provide a tonic vasodilator influence and tested that hypothesis by measuring cerebral blood flow in anesthetized rats before and after removal of a pterygopalatine ganglion. Ganglion removal led to reduced cerebral blood flow without changing blood pressure. Thus, parasympathetic nerves provide tonic vasodilatory input to cerebral blood vessels.

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