Cellular and Network Mechanisms of Electrographic Seizures

Overview

Journal Drug Discov Today Dis Models

Publisher Elsevier

Date 2009 Feb 5

PMID 19190736

Citations 26

Authors

Maxim Bazhenov

Igor Timofeev

Flavio Frohlich

Terrence J Sejnowski

Affiliations

Soon will be listed here.

Abstract

Epileptic seizures constitute a complex multiscale phenomenon that is characterized by synchronized hyperexcitation of neurons in neuronal networks. Recent progress in understanding pathological seizure dynamics provides crucial insights into underlying mechanisms and possible new avenues for the development of novel treatment modalities. Here we review some recent work that combines in vivo experiments and computational modeling to unravel the pathophysiology of seizures of cortical origin. We particularly focus on how activity-dependent changes in extracellular potassium concentration affects the intrinsic dynamics of neurons involved in cortical seizures characterized by spike/wave complexes and fast runs.

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