Why We Should Put Clothes on Mice

Overview

Journal Cell Metab

Publisher Cell Press

Specialties Cell Biology
Endocrinology

Date 2009 Feb 4

PMID 19187768

Citations 51

Authors

Irfan J Lodhi

Clay F Semenkovich

Affiliations

Soon will be listed here.

Abstract

Mitochondrial uncoupling protein 1 (UCP1) is a key regulator of adaptive thermogenesis and energy expenditure. Mice lacking UCP1 are cold sensitive, but surprisingly not obese at room temperature. In this issue of Cell Metabolism, Feldmann et al. (2009) unmask an obesogenic phenotype by simply maintaining these mice at thermoneutrality.

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