MAP'ing CNS Development and Cognition: an ERKsome Process

Overview

Journal Neuron

Publisher Cell Press

Specialty Neurology

Date 2009 Feb 3

PMID 19186160

Citations 104

Authors

Ivy S Samuels

Sulagna C Saitta

Gary E Landreth

Affiliations

Soon will be listed here.

Abstract

The ERK MAP kinase signaling cascade plays critical roles in brain development, learning, memory, and cognition. It has recently been appreciated that mutation or deletion of elements within this signaling pathway leads to developmental syndromes in humans that are associated with impaired cognitive function and autism. Here, we review recent studies that provide insight into the biological roles of the ERKs in the brain that may underlie the cognitive deficits seen in these syndromes.

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