Hypoxia-inducible Factor in Cancer Angiogenesis: Structure, Regulation and Clinical Perspectives

Overview

Journal Crit Rev Oncol Hematol

Specialty Hematology

Date 2009 Feb 3

PMID 19186072

Citations 31

Authors

Zaher K Otrock

Hassan A Hatoum

Ahmad H Awada

Rim S Ishak

Ali I Shamseddine

Affiliations

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Abstract

Tumor hypoxia is a common feature of many cancers. A master regulator of hypoxic response is the transcription factor hypoxia-inducible factor-1 (HIF-1). It functions as a master regulator of oxygen and undergoes conformational changes in response to varying oxygen concentrations. In this paper, we review what has been described about HIF-1: its structure, its regulation and target genes, its role in cancer, and its implication for cancer therapy.

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