Congenital Long-QT Syndromes: a Clinical and Genetic Update from Infancy Through Adulthood

Overview

Journal Trends Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2009 Feb 3

PMID 19185812

Citations 9

Authors

Gregory Webster

Charles I Berul

Affiliations

Soon will be listed here.

Abstract

Long-QT syndromes (LQTSs) have been described in all ages and are a significant cause of cardiovascular mortality, especially in structurally normal hearts. Abnormalities in transmembrane ion conduction channels and structural proteins produce these clinical syndromes, labeled LQT1-LQT12; however, genotype-positive patients still represent only about 70% of LQTSs. Future research will determine the etiology of the remaining cases, further risk-stratify the known genetic defects, improve current treatment options for these syndromes, and uncover novel therapies.

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