Morphological Changes in the Retinal Pigment Epithelium on Spectral-domain OCT in the Unaffected Eyes with Idiopathic Central Serous Chorioretinopathy

Overview

Journal Int Ophthalmol

Specialty Ophthalmology

Date 2009 Feb 3

PMID 19183854

Citations 17

Authors

Pawan Gupta

Vishali Gupta

M R Dogra

Ramandeep Singh

Amod Gupta

Affiliations

Soon will be listed here.

Abstract

Purpose: To report the changes seen in the retinal pigment epithelium (RPE) morphology in the asymptomatic eyes of patients with idiopathic central serous chorioretinopathy (ICSC) using spectral-domain Cirrus (TM) high-definition optical coherence tomography (HD-OCT).

Methods: In a prospective case series, 17 consecutive patients with unilateral ICSC underwent spectral-domain Cirrus (TM) HD-OCT scans for both affected and opposite asymptomatic eye. Three-dimensional single-layer RPE map was studied in both eyes for morphological alterations, and findings were correlated with clinical presentation, fluorescein angiogram, and 5 Line raster scan. Additionally, three-dimensional (3D) single-layer RPE maps done in 111 healthy volunteers served as control.

Results: In patients with ICSC, 3D single-layer RPE analysis of asymptomatic eyes showed presence of RPE bumps in 16 (94%) eyes and pigment epithelium detachment (PED) in 2 (11.8%) eyes. The 5 Line raster scan was normal in all eyes. Of 222 normal (control) scans, 18 showed RPE bumps and none showed PED. Conclusions 3D single-layer RPE map showed abnormal pattern in the asymptomatic eyes of patients with unilateral ICSC.

Summary: Spectral-domain optical coherence tomography showed morphologic alterations in retinal pigment epithelium in both eyes of patients with idiopathic central serous chorioretinopathy.

Citing Articles

Central Serous Chorioretinopathy by Autofluorescence, Enface and SLO-Retromode Imaging.

Savastano M, Fossataro C, Sadun R, Scupola A, Sammarco M, Rizzo C Life (Basel). 2023; 13(6).

PMID: 37374191 PMC: 10304114. DOI: 10.3390/life13061407.

Three-dimensional choroidal vascularity index in central serous chorioretinopathy using ultra-widefield swept-source optical coherence tomography angiography.

Zeng Q, Luo L, Yao Y, Tu S, Yang Z, Zhao M Front Med (Lausanne). 2022; 9:967369.

PMID: 36160148 PMC: 9490028. DOI: 10.3389/fmed.2022.967369.

Fundus Autofluorescence and Optical Coherence Tomography Characteristics in Different Stages of Central Serous Chorioretinopathy.

Ho M, Kwok S, Mak A, Lai F, Ng D, Chen L J Ophthalmol. 2021; 2021:6649064.

PMID: 34194820 PMC: 8184321. DOI: 10.1155/2021/6649064.

Central Serous Chorioretinopathy Classification.

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Comparison of Retinal Layer Thickness and Capillary Vessel Density in the Patients with Spontaneously Resolved Acute Central Serous Chorioretinopathy.

Han K, Ju Kim H, Woo J, Min J J Clin Med. 2020; 10(1).

PMID: 33375674 PMC: 7795401. DOI: 10.3390/jcm10010045.

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