Pharmacokinetics of Ceftriaxone

Overview

Journal Hosp Pract (Off Ed)

Specialty Health Services

Date 1991 Sep 1

PMID 1918224

Citations 5

Authors

J Blumer

Affiliations

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Abstract

Ceftriaxone fulfills many of the qualities of an ideal antibiotic: a prolonged elimination half-life, which results from a "restrictive" excretion pattern; saturable protein binding, which provides the theoretical basis for administering the total daily dose as a single bolus; and once-a-day dosing, which provides plasma and tissue concentrations that exceed the MIC for most susceptible pathogens for 24 hours.

Citing Articles

Wound fluid ceftriaxone concentrations after local application with calcium sulphate as carrier material in the treatment of orthopaedic device-associated hip infections.

Wiesli M, Livio F, Achermann Y, Gautier E, Wahl P Bone Joint Res. 2022; 11(11):835-842.

PMID: 36384300 PMC: 9680198. DOI: 10.1302/2046-3758.1111.BJR-2022-0180.R1.

Safety of ceftriaxone in paediatrics: a systematic review protocol.

Zeng L, Choonara I, Zhang L, Xue S, Chen Z, He M BMJ Open. 2017; 7(8):e016273.

PMID: 28827252 PMC: 5634450. DOI: 10.1136/bmjopen-2017-016273.

Antibiotics and breast-feeding: a critical review of the literature.

Chung A, Reed M, Blumer J Paediatr Drugs. 2002; 4(12):817-37.

PMID: 12431134 DOI: 10.2165/00128072-200204120-00006.

Clinical use of ceftriaxone: a pharmacokinetic-pharmacodynamic perspective on the impact of minimum inhibitory concentration and serum protein binding.

Perry T, Schentag J Clin Pharmacokinet. 2001; 40(9):685-94.

PMID: 11605716 DOI: 10.2165/00003088-200140090-00004.

Effect of gentamicin dosing interval on efficacy of penicillin or ceftriaxone treatment of experimental endocarditis due to penicillin-susceptible, ceftriaxone-tolerant viridans group streptococci.

Brandt C, Warner C, Rouse M, Steckelberg J, Wilson W Antimicrob Agents Chemother. 1996; 40(12):2901-3.

PMID: 9124865 PMC: 163646. DOI: 10.1128/AAC.40.12.2901.