Knocking Down Barriers: Advances in SiRNA Delivery

Overview

Journal Nat Rev Drug Discov

Specialty Pharmacology

Date 2009 Jan 31

PMID 19180106

Citations 1075

Authors

Kathryn A Whitehead

Robert Langer

Daniel G Anderson

Affiliations

Soon will be listed here.

Abstract

In the 10 years that have passed since the Nobel prize-winning discovery of RNA interference (RNAi), billions of dollars have been invested in the therapeutic application of gene silencing in humans. Today, there are promising data from ongoing clinical trials for the treatment of age-related macular degeneration and respiratory syncytial virus. Despite these early successes, however, the widespread use of RNAi therapeutics for disease prevention and treatment requires the development of clinically suitable, safe and effective drug delivery vehicles. Here, we provide an update on the progress of RNAi therapeutics and highlight novel synthetic materials for the encapsulation and intracellular delivery of nucleic acids.

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