Calcium-activated K+ Channels: Metabolic Regulation

Overview

Journal J Bioenerg Biomembr

Publisher Springer

Specialties Biochemistry
Biology
Endocrinology

Date 1991 Aug 1

PMID 1917909

Citations 5

Authors

L Toro

E Stefani

Affiliations

Soon will be listed here.

Abstract

Calcium-activated potassium (KCa) channels are highly modulated by a large spectrum of metabolites. Neurotransmitters, hormones, lipids, and nucleotides are capable of activating and/or inhibiting KCa channels. Studies from the last few years have shown that metabolites modulate the activity of KCa channels via: (1) a change in the affinity of the channel for Ca2+ (K 1/2 is modified), (2) a parallel shift in the voltage axis of the activation curves, or (3) a change in the slope (effective valence) of the voltage dependence curve. The shift of the voltage dependence curve can be a direct consequence of the change in the affinity for Ca2+. Recently, the mechanistic steps involved in the modulation of KCa channels are being uncovered. Some interactions may be direct on KCa channels and others may be mediated via G-proteins, second messengers, or phosphorylation. The information given in this review highlights the possibility that KCa channels can be activated or inhibited by metabolites without a change in the intracellular Ca2+ concentration.

Citing Articles

Reciprocal regulation of the Ca2+ and H+ sensitivity in the SLO1 BK channel conferred by the RCK1 domain.

Hou S, Xu R, Heinemann S, Hoshi T Nat Struct Mol Biol. 2008; 15(4):403-10.

PMID: 18345016 PMC: 2905141. DOI: 10.1038/nsmb.1398.

Oxidative regulation of large conductance calcium-activated potassium channels.

Tang X, Daggett H, Hanner M, Garcia M, McManus O, Brot N J Gen Physiol. 2001; 117(3):253-74.

PMID: 11222629 PMC: 2225619. DOI: 10.1085/jgp.117.3.253.

A novel type of ATP block on a Ca(2+)-activated K(+) channel from bullfrog erythrocytes.

Shindo M, Imai Y, Sohma Y Biophys J. 2000; 79(1):287-97.

PMID: 10866955 PMC: 1300933. DOI: 10.1016/S0006-3495(00)76291-6.

Synthesis of models for excitable membranes, synaptic transmission and neuromodulation using a common kinetic formalism.

Destexhe A, Mainen Z, Sejnowski T J Comput Neurosci. 1994; 1(3):195-230.

PMID: 8792231 DOI: 10.1007/BF00961734.

Highly co-operative Ca2+ activation of intermediate-conductance K+ channels in granulocytes from a human cell line.

Varnai P, Demaurex N, Jaconi M, Schlegel W, Lew D, Krause K J Physiol. 1993; 472:373-90.

PMID: 7511688 PMC: 1160492. DOI: 10.1113/jphysiol.1993.sp019952.

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