Therapeutic Antioxidant Medical Gas

Overview

Journal J Clin Biochem Nutr

Specialty Biochemistry

Date 2009 Jan 30

PMID 19177183

Citations 46

Authors

Atsunori Nakao

Ryujiro Sugimoto

Timothy R Billiar

Kenneth R McCurry

Affiliations

Soon will be listed here.

Abstract

Medical gases are pharmaceutical gaseous molecules which offer solutions to medical needs and include traditional gases, such as oxygen and nitrous oxide, as well as gases with recently discovered roles as biological messenger molecules, such as carbon monoxide, nitric oxide and hydrogen sulphide. Medical gas therapy is a relatively unexplored field of medicine; however, a recent increasing in the number of publications on medical gas therapies clearly indicate that there are significant opportunities for use of gases as therapeutic tools for a variety of disease conditions. In this article, we review the recent advances in research on medical gases with antioxidant properties and discuss their clinical applications and therapeutic properties.

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References

Nunoshiba T, Wishnok J, Tannenbaum S, Demple B . Activation by nitric oxide of an oxidative-stress response that defends Escherichia coli against activated macrophages. Proc Natl Acad Sci U S A. 1993; 90(21):9993-7. PMC: 47699. DOI: 10.1073/pnas.90.21.9993. View

Fujita T, Toda K, Karimova A, Yan S, Naka Y, Yet S . Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis. Nat Med. 2001; 7(5):598-604. DOI: 10.1038/87929. View

Redl H, Bahrami S, Schlag G, Traber D . Clinical detection of LPS and animal models of endotoxemia. Immunobiology. 1993; 187(3-5):330-45. DOI: 10.1016/S0171-2985(11)80348-7. View

Nunomura A, Moreira P, Takeda A, Smith M, Perry G . Oxidative RNA damage and neurodegeneration. Curr Med Chem. 2008; 14(28):2968-75. DOI: 10.2174/092986707782794078. View

Tamura Y, Imaoka S, Gemba M, Funae Y . Effects of ischemia-reperfusion on individual cytochrome P450 isoforms in the rat kidney. Life Sci. 1997; 60(2):143-9. DOI: 10.1016/s0024-3205(96)00604-2. View

Glende Jr E, Hruszkewycz A, RECKNAGEL R . Critical role of lipid peroxidation in carbon tetrachloride-induced loss of aminopyrine demethylase, cytochrome P-450 and glucose 6-phosphatase. Biochem Pharmacol. 1976; 25(19):2163-70. DOI: 10.1016/0006-2952(76)90128-3. View

Nakahira K, Takahashi T, Shimizu H, Maeshima K, Uehara K, Fujii H . Protective role of heme oxygenase-1 induction in carbon tetrachloride-induced hepatotoxicity. Biochem Pharmacol. 2003; 66(6):1091-105. DOI: 10.1016/s0006-2952(03)00444-1. View

Chen H, Xing B, Liu X, Zhan B, Zhou J, Zhu H . Ozone oxidative preconditioning inhibits inflammation and apoptosis in a rat model of renal ischemia/reperfusion injury. Eur J Pharmacol. 2007; 581(3):306-14. DOI: 10.1016/j.ejphar.2007.11.050. View

Mayr F, Spiel A, Leitner J, Marsik C, Germann P, Ullrich R . Effects of carbon monoxide inhalation during experimental endotoxemia in humans. Am J Respir Crit Care Med. 2004; 171(4):354-60. DOI: 10.1164/rccm.200404-446OC. View

10.

Di Paolo N, Bocci V, Salvo D, Palasciano G, Biagioli M, Meini S . Extracorporeal blood oxygenation and ozonation (EBOO): a controlled trial in patients with peripheral artery disease. Int J Artif Organs. 2005; 28(10):1039-50. DOI: 10.1177/039139880502801012. View

11.

Ajamieh H, Merino N, Candelario-Jalil E, Menendez S, Martinez-Sanchez G, Re L . Similar protective effect of ischaemic and ozone oxidative preconditionings in liver ischaemia/reperfusion injury. Pharmacol Res. 2002; 45(4):333-9. DOI: 10.1006/phrs.2002.0952. View

12.

Akamatsu Y, Haga M, Tyagi S, Yamashita K, Graca-Souza A, Ollinger R . Heme oxygenase-1-derived carbon monoxide protects hearts from transplant associated ischemia reperfusion injury. FASEB J. 2004; 18(6):771-2. DOI: 10.1096/fj.03-0921fje. View

13.

David H, Haelewyn B, Rouillon C, Lecoq M, Chazalviel L, Apiou G . Neuroprotective effects of xenon: a therapeutic window of opportunity in rats subjected to transient cerebral ischemia. FASEB J. 2007; 22(4):1275-86. DOI: 10.1096/fj.07-9420com. View

14.

Parsons C, Danysz W, Hesselink M, Hartmann S, Lorenz B, Wollenburg C . Modulation of NMDA receptors by glycine--introduction to some basic aspects and recent developments. Amino Acids. 1999; 14(1-3):207-16. DOI: 10.1007/BF01345264. View

15.

Lundberg J, Weitzberg E, Gladwin M . The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov. 2008; 7(2):156-67. DOI: 10.1038/nrd2466. View

16.

Di Paolo N, Bocci V, Gaggiotti E . Ozone therapy. Int J Artif Organs. 2004; 27(3):168-75. DOI: 10.1177/039139880402700303. View

17.

Beauchamp Jr R, Bus J, Popp J, Boreiko C, Andjelkovich D . A critical review of the literature on hydrogen sulfide toxicity. Crit Rev Toxicol. 1984; 13(1):25-97. DOI: 10.3109/10408448409029321. View

18.

Klimisch H, Chevalier H, Harke H, DONTENWILL W . Uptake of carbon monoxide in blood of miniture pigs and other mammals. Toxicology. 1975; 3(3):301-10. DOI: 10.1016/0300-483x(75)90031-1. View

19.

Bocci V . Ozone as Janus: this controversial gas can be either toxic or medically useful. Mediators Inflamm. 2004; 13(1):3-11. PMC: 1781533. DOI: 10.1080/0962935062000197083. View

20.

Dragun D, Hoff U, Park J, Qun Y, Schneider W, Luft F . Prolonged cold preservation augments vascular injury independent of renal transplant immunogenicity and function. Kidney Int. 2001; 60(3):1173-81. DOI: 10.1046/j.1523-1755.2001.0600031173.x. View