Phosphorylation Keeps PTEN Phosphatase Closed for Business

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2009 Jan 29

PMID 19174524

Citations 41

Authors

Alonzo H Ross

Arne Gericke

Affiliations

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References

Odriozola L, Singh G, Hoang T, Chan A . Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain. J Biol Chem. 2007; 282(32):23306-15. DOI: 10.1074/jbc.M611240200. View

Iijima M, Huang Y, Luo H, Vazquez F, Devreotes P . Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis. J Biol Chem. 2004; 279(16):16606-13. DOI: 10.1074/jbc.M312098200. View

Boegeman S, Deems R, Dennis E . Phospholipid binding and the activation of group IA secreted phospholipase A2. Biochemistry. 2004; 43(13):3907-16. DOI: 10.1021/bi035921b. View

Leslie N, Downes C . PTEN function: how normal cells control it and tumour cells lose it. Biochem J. 2004; 382(Pt 1):1-11. PMC: 1133909. DOI: 10.1042/BJ20040825. View

Rahdar M, Inoue T, Meyer T, Zhang J, Vazquez F, Devreotes P . A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. Proc Natl Acad Sci U S A. 2008; 106(2):480-5. PMC: 2626728. DOI: 10.1073/pnas.0811212106. View

Das S, Dixon J, Cho W . Membrane-binding and activation mechanism of PTEN. Proc Natl Acad Sci U S A. 2003; 100(13):7491-6. PMC: 164614. DOI: 10.1073/pnas.0932835100. View

Lee J, Yang H, Georgescu M, Di Cristofano A, Maehama T, Shi Y . Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell. 1999; 99(3):323-34. DOI: 10.1016/s0092-8674(00)81663-3. View

Campbell R, Liu F, Ross A . Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate. J Biol Chem. 2003; 278(36):33617-20. DOI: 10.1074/jbc.C300296200. View

Vazquez F, Grossman S, Takahashi Y, Rokas M, Nakamura N, Sellers W . Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. J Biol Chem. 2001; 276(52):48627-30. DOI: 10.1074/jbc.C100556200. View

10.

Vazquez F, Ramaswamy S, Nakamura N, Sellers W . Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol. 2000; 20(14):5010-8. PMC: 85951. DOI: 10.1128/MCB.20.14.5010-5018.2000. View

11.

Kelleher 3rd R, Bear M . The autistic neuron: troubled translation?. Cell. 2008; 135(3):401-6. DOI: 10.1016/j.cell.2008.10.017. View

12.

Maehama T, Dixon J . The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem. 1998; 273(22):13375-8. DOI: 10.1074/jbc.273.22.13375. View

13.

Walker S, Leslie N, Perera N, Batty I, Downes C . The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif. Biochem J. 2004; 379(Pt 2):301-7. PMC: 1224073. DOI: 10.1042/BJ20031839. View

14.

Mulgrew-Nesbitt A, Diraviyam K, Wang J, Singh S, Murray P, Li Z . The role of electrostatics in protein-membrane interactions. Biochim Biophys Acta. 2006; 1761(8):812-26. DOI: 10.1016/j.bbalip.2006.07.002. View

15.

McConnachie G, Pass I, Walker S, Downes C . Interfacial kinetic analysis of the tumour suppressor phosphatase, PTEN: evidence for activation by anionic phospholipids. Biochem J. 2003; 371(Pt 3):947-55. PMC: 1223325. DOI: 10.1042/BJ20021848. View

16.

Walsh C, Morrow E, Rubenstein J . Autism and brain development. Cell. 2008; 135(3):396-400. PMC: 2701104. DOI: 10.1016/j.cell.2008.10.015. View

17.

Wishart M, Dixon J . PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease. Trends Cell Biol. 2002; 12(12):579-85. DOI: 10.1016/s0962-8924(02)02412-1. View

18.

Li L, Ross A . Why is PTEN an important tumor suppressor?. J Cell Biochem. 2007; 102(6):1368-74. DOI: 10.1002/jcb.21593. View

19.

Redfern R, Redfern D, Furgason M, Munson M, Ross A, Gericke A . PTEN phosphatase selectively binds phosphoinositides and undergoes structural changes. Biochemistry. 2008; 47(7):2162-71. DOI: 10.1021/bi702114w. View

20.

Vazquez F, Matsuoka S, Sellers W, Yanagida T, Ueda M, Devreotes P . Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane. Proc Natl Acad Sci U S A. 2006; 103(10):3633-8. PMC: 1450134. DOI: 10.1073/pnas.0510570103. View