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Published International Classification of Retinoblastoma (ICRB) Definitions Contain Inconsistencies--an Analysis of Impact

Overview
Publisher Informa Healthcare
Specialties Genetics
Ophthalmology
Date 2009 Jan 28
PMID 19172510
Citations 25
Authors
Affiliations
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Abstract

Purpose: To determine the impact of subtle differences (most notably in their classification of group E eyes) in two published versions of the ICRB (Philadelphia and the Children's Hospital Los Angeles).

Methods: Analysis of a series of 96 eyes with intra-ocular retinoblastoma.

Results: The disparate criteria of the 2 published ICRB schemas affected group assignment of 5.2% of the eyes (25% of the group E eyes).

Conclusion: Discrepancies need to be reconciled to ensure accurate and uniform application of the ICRB.

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