Prevalence of Hepatitis C Virus (HCV) Coinfection in HIV Infected Individuals in South India and Characterization of HCV Genotypes

Overview

Journal Indian J Med Microbiol

Publisher Elsevier

Specialty Microbiology

Date 2009 Jan 28

PMID 19172052

Citations 9

Authors

S P D Ponamgi

S Rahamathulla

Y N Kumar

M Chandra

N Lakshmi

C M Habibullah

M N Khaja

Affiliations

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Abstract

Purpose: To determine anti-HCV antibodies and genomic subtype of HCV in 1487 confirmed human immunodeficiency virus (HIV) positive samples.

Methods: A total of 1487 confirmed HIV-positive samples were tested for anti-HCV antibodies by using a third generation ELISA kit (Ortho 3.0) and by RT PCR for HCV. HIV and HCV coinfected samples were selected for HCV genotyping by RFLP and subtyping with NS5-type specific primers.

Results: A total of 1487 HIV-infected serum samples were screened for HCV infection, of which, a 1443 (97.04%) were negative and 45 (3.02%) were coinfected. HIV-HCV coinfection was predominant in the age group 41-50 years (51.1%). HCV genotyping and subtyping was done for the 45 HCV RNA-positive specimens of which genotype 1 was observed in 31 (68.8%) and genotype 3 was observed in 14 (31.1%) subjects. Further subtyping analysis showed the genotype 1b in 23 (51.1%), 1a in eight (17.7%), 3a in 10 (22.2%) and 3b in four (8.8%) subjects.

Conclusion: HIV and HCV seroprevalence is higher in South India, and the most prevalent genotype in coinfection was genotype 1b.

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