Prevention of Non-communicable Disease in a Population in Nutrition Transition: Tehran Lipid and Glucose Study Phase II

Overview

Journal Trials

Publisher Biomed Central

Specialties General Medicine
Pharmacology

Date 2009 Jan 27

PMID 19166627

Citations 396

Authors

Fereidoun Azizi

Arash Ghanbarian

Amir Abbas Momenan

Farzad Hadaegh

Parvin Mirmiran

Mehdi Hedayati

Yadollah Mehrabi

Saleh Zahedi-Asl

Affiliations

Soon will be listed here.

Abstract

Background: The Tehran Lipid and Glucose Study (TLGS) is a long term integrated community-based program for prevention of non-communicable disorders (NCD) by development of a healthy lifestyle and reduction of NCD risk factors. The study begun in 1999, is ongoing, to be continued for at least 20 years. A primary survey was done to collect baseline data in 15005 individuals, over 3 years of age, selected from cohorts of three medical heath centers. A questionnaire for past medical history and data was completed during interviews; blood pressure, pulse rate, and anthropometrical measurements and a limited physical examination were performed and lipid profiles, fasting blood sugar and 2-hours-postload-glucose challenge were measured. A DNA bank was also collected. For those subjects aged over 30 years, Rose questionnaire was completed and an electrocardiogram was taken. Data collected were directly stored in computers as database software- computer assisted system. The aim of this study is to evaluate the feasibility and effectiveness of lifestyle modification in preventing or postponing the development of NCD risk factors and outcomes in the TLGS population.

Design And Methods: In phase II of the TLGS, lifestyle interventions were implemented in 5630 people and 9375 individuals served as controls. Primary, secondary and tertiary interventions were designed based on specific target groups including schoolchildren, housewives, and high-risk persons. Officials of various sectors such as health, education, municipality, police, media, traders and community leaders were actively engaged as decision makers and collaborators. Interventional strategies were based on lifestyle modifications in diet, smoking and physical activity through face-to-face education, leaflets & brochures, school program alterations, training volunteers as health team and treating patients with NCD risk factors. Collection of demographic, clinical and laboratory data will be repeated every 3 years to assess the effects of different interventions in the intervention group as compared to control group.

Conclusion: This controlled community intervention will test the possibility of preventing or delaying the onset of non-communicable risk factors and disorders in a population in nutrition transition.

Trial Registration: ISRCTN52588395.

Citing Articles

Optimal Cut-off Points of the Standardized Continuous Metabolic Syndrome Severity Score (cMetS-S) for Predicting Cardiovascular Disease (CVD) and CVD Mortality in the Tehran Lipid and Glucose Study (TLGS).

Adib M, Mehran L, Masoumi S, Vatanpoor I, Azizi F, Amouzegar A Int J Endocrinol Metab. 2025; 22(4):e154255.

PMID: 40071054 PMC: 11892520. DOI: 10.5812/ijem-154255.

A pragmatic multi-setting healthy lifestyle intervention to improve BMI status in a middle-income population: A potential strategy for individuals at risk.

Yari-Boroujeni R, Cheraghi L, Parvin P, Shiravi F, Masihay-Akbar H, Momenan A Health Promot Perspect. 2025; 14(4):369-379.

PMID: 40041731 PMC: 11873776. DOI: 10.34172/hpp.43196.

Barriers and facilitators of self-care in adults with pre-diabetes: a directed qualitative content analysis.

Jokar M, Zandi M, Ebadi A, Momenan A, Rostamkhani M BMC Health Serv Res. 2025; 25(1):332.

PMID: 40033296 PMC: 11877960. DOI: 10.1186/s12913-025-12407-3.

Genetic and environmental contribution to phenotypic resemblance between Iranian couples: Tehran Cardiometabolic and Genetic Study (TCGS).

Riahi P, Saeidian A, Tenesa A, Hogan C, March M, Guity K Heliyon. 2025; 11(3):e42401.

PMID: 39995917 PMC: 11849086. DOI: 10.1016/j.heliyon.2025.e42401.

Associations between spice or pepper (Capsicum annuum) consumption and diabetes or metabolic syndrome incidence.

Ildarabadi A, Hosseini-Esfahani F, Daei S, Mirmiran P, Azizi F PLoS One. 2025; 20(2):e0314448.

PMID: 39932911 PMC: 11813124. DOI: 10.1371/journal.pone.0314448.

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