Vascular Endothelial Growth Factor

Overview

Journal Arterioscler Thromb Vasc Biol

Date 2009 Jan 24

PMID 19164810

Citations 187

Authors

Napoleone Ferrara

Affiliations

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Abstract

Vascular endothelial growth factor (VEGF, VEGF-A) is a major regulator of physiological and pathological angiogenesis. Several VEGF inhibitors have been approved by the FDA for the treatment of advanced cancer and neovascular age-related macular degeneration. This brief review provides a historic account of the challenges associated with the discovery of VEGF and the early steps in elucidating the role of this molecule in the regulation of angiogenesis.

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