Asymmetric Synthesis of Medium-sized Rings by Intramolecular Au(I)-catalyzed Cyclopropanation

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2009 Jan 24

PMID 19161306

Citations 30

Authors

Iain D G Watson

Stefanie Ritter

F Dean Toste

Affiliations

Soon will be listed here.

Abstract

An efficient method for the asymmetric gold(I)-catalyzed preparation of medium sized rings has been developed. The method provides 7- to 9-membered rings in excellent yield. High enantioselectivities can be achieved for 7- and 8-membered ring products employing chiral gold(I) complexes. The results provide insight into the mechanism, showing the fluxional nature of gold(I)-stabilized vinyl carbenoid intermediates.

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