Does Helicobacter Pylori-induced Inflammation of Gastric Mucosa Determine the Severity of Symptoms in Functional Dyspepsia?

Overview

Journal J Gastroenterol

Specialty Gastroenterology

Date 2009 Jan 23

PMID 19159074

Citations 12

Authors

Ebru Turkkan

Ihsan Uslan

Gursel Acarturk

Nevin Topak

Ahmet Kahraman

Fatma Husniye Dilek

Yusuf Akcan

Ozcan Karaman

Mehmet Colbay

Seref Yuksel

Affiliations

Soon will be listed here.

Abstract

Background: Inflammation induces some structural and biochemical alterations and oxidative damage in gastric tissue. In this study, we aimed to investigate the relationship among the severity of symptoms, oxidative stress, and grading scales of Helicobacter pylori-induced gastric inflammation in functional dyspepsia.

Methods: Thirty-five patients with functional dyspepsia were enrolled in the study. The severity of dyspepsia within the last 6 months was evaluated by Glasgow Dyspepsia Severity Score. In biopsy specimens of gastric mucosa, severity of gastritis was estimated by the revised Sydney Classification System, and oxidative stress parameters were studied.

Results: Although there was no statistically significant relationship between symptom scores and degree of chronic inflammation, a tendency for symptoms to be more severe has been observed in low levels of gastritis. Levels of sulfhydryl groups were lower in subjects with high levels of chronic inflammation, and Helicobacter pylori intensity (P < 0.001 and P = 0.02, respectively). Levels of malondialdehyde were higher in subjects with high levels of chronic inflammation (P = 0.04). There was a statistically significant but a weak positive correlation between symptom scores and sulfhydryl levels (P < 0.001, r = 0.323).

Conclusions: In conclusion, there may be an inverse relation between severity of symptoms and level of Helicobacter pylori induced gastric inflammation or oxidative stress in patients with functional dyspepsia.

Citing Articles

Zhizhu Kuanzhong Capsule in treating patients with functional dyspepsia postprandial distress syndrome: study protocol for a multicenter, randomized, double-blind, placebo-controlled, parallel-group clinical trial.

Xiao M, Zhong L, Lam W, Zhao Y, Gwee K, Holtmann G Trials. 2022; 23(1):454.

PMID: 35655286 PMC: 9161179. DOI: 10.1186/s13063-022-06396-5.

Quercetin Improves Mitochondrial Function and Inflammation in HO-Induced Oxidative Stress Damage in the Gastric Mucosal Epithelial Cell by Regulating the PI3K/AKT Signaling Pathway.

Yao X, Mei Y, Mao W Evid Based Complement Alternat Med. 2021; 2021:1386078.

PMID: 34873406 PMC: 8643250. DOI: 10.1155/2021/1386078.

Comparison of clinical symptoms after eradication in functional dyspepsia patients based on endoscopic view of antral gastropathy.

Azadbakht S, Esmaili A, Rahmani P New Microbes New Infect. 2020; 38:100806.

PMID: 33365132 PMC: 7749399. DOI: 10.1016/j.nmni.2020.100806.

Functional Dyspepsia: Diagnostic and Therapeutic Approaches.

Sayuk G, Gyawali C Drugs. 2020; 80(13):1319-1336.

PMID: 32691294 DOI: 10.1007/s40265-020-01362-4.

Neutrophil-activating Protein Polymorphism of Helicobacter pylori Determines the Host Risk of Dyspepsia.

Matsuzaki J, Tsugawa H, Kashiwazaki Y, Mori H, Yamamoto Y, Kameyama H Cell Mol Gastroenterol Hepatol. 2019; 8(2):295-297.e6.

PMID: 31108232 PMC: 6718361. DOI: 10.1016/j.jcmgh.2019.05.004.

References

Leahy A, Besherdas K, Clayman C, Mason I, Epstein O . Abnormalities of the electrogastrogram in functional gastrointestinal disorders. Am J Gastroenterol. 1999; 94(4):1023-8. DOI: 10.1111/j.1572-0241.1999.01007.x. View

Guarner J, Herrera-Goepfert R, Mohar A, Sanchez L, Halperin D, Ley C . Interobserver variability in application of the revised Sydney classification for gastritis. Hum Pathol. 2000; 30(12):1431-4. DOI: 10.1016/s0046-8177(99)90164-8. View

Ohkawa H, Ohishi N, Yagi K . Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979; 95(2):351-8. DOI: 10.1016/0003-2697(79)90738-3. View

Tepes B, Kavcic B, Zaletel L, Gubina M, Ihan A, Poljak M . Two- to four-year histological follow-up of gastric mucosa after Helicobacter pylori eradication. J Pathol. 1999; 188(1):24-9. DOI: 10.1002/(sici)1096-9896(199905)188:1<24::aid-path316>3.0.co;2-f. View

Bortolotti M, Coccia G, Grossi G, Miglioli M . The treatment of functional dyspepsia with red pepper. Aliment Pharmacol Ther. 2002; 16(6):1075-82. DOI: 10.1046/j.1365-2036.2002.01280.x. View

Bruley des Varannes S, Flejou J, Colin R, Zaim M, Meunier A, Bidaut-Mazel C . There are some benefits for eradicating Helicobacter pylori in patients with non-ulcer dyspepsia. Aliment Pharmacol Ther. 2001; 15(8):1177-85. DOI: 10.1046/j.1365-2036.2001.01014.x. View

Rosenstock S, Kay L, Rosenstock C, Andersen L, Bonnevie O, Jorgensen T . Relation between Helicobacter pylori infection and gastrointestinal symptoms and syndromes. Gut. 1997; 41(2):169-76. PMC: 1891470. DOI: 10.1136/gut.41.2.169. View

Narita M, Takahashi S, Takeuchi K, Okabe S . Desensitization of capsaicin-sensitive sensory neurons in rat stomachs on chronic treatment with sodium taurocholate. Jpn J Pharmacol. 1995; 67(4):321-8. DOI: 10.1254/jjp.67.321. View

Tornblom H, Lindberg G, Nyberg B, Veress B . Full-thickness biopsy of the jejunum reveals inflammation and enteric neuropathy in irritable bowel syndrome. Gastroenterology. 2002; 123(6):1972-9. DOI: 10.1053/gast.2002.37059. View

10.

van der Schaar P, Straathof J, Veenendaal R, Lamers C, Masclee A . Does Helicobacter pylori gastritis affect motor function of proximal stomach in dyspeptic patients?. Dig Dis Sci. 2001; 46(9):1833-8. DOI: 10.1023/a:1010662409847. View

11.

El-Omar E, Banerjee S, Wirz A, McColl K . The Glasgow Dyspepsia Severity Score--a tool for the global measurement of dyspepsia. Eur J Gastroenterol Hepatol. 1996; 8(10):967-71. DOI: 10.1097/00042737-199610000-00006. View

12.

Demir S, Yilmaz M, Koseoglu M, Akalin N, Aslan D, Aydin A . Role of free radicals in peptic ulcer and gastritis. Turk J Gastroenterol. 2003; 14(1):39-43. View

13.

Quartero A, de Wit N, Lodder A, Numans M, Smout A, Hoes A . Disturbed solid-phase gastric emptying in functional dyspepsia: a meta-analysis. Dig Dis Sci. 1998; 43(9):2028-33. DOI: 10.1023/a:1018803129779. View

14.

Phull P, Price A, Stephens J, Rathbone B, Jacyna M . Histology of chronic gastritis with and without duodenitis in patients with Helicobacter pylori infection. J Clin Pathol. 1996; 49(5):377-80. PMC: 500475. DOI: 10.1136/jcp.49.5.377. View

15.

Talley N, Stanghellini V, Heading R, Koch K, Malagelada J, Tytgat G . Functional gastroduodenal disorders. Gut. 1999; 45 Suppl 2:II37-42. PMC: 1766695. DOI: 10.1136/gut.45.2008.ii37. View

16.

Levine R, Garland D, Oliver C, Amici A, Climent I, Lenz A . Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol. 1990; 186:464-78. DOI: 10.1016/0076-6879(90)86141-h. View

17.

Koch K, Hong S, Xu L . Reproducibility of gastric myoelectrical activity and the water load test in patients with dysmotility-like dyspepsia symptoms and in control subjects. J Clin Gastroenterol. 2000; 31(2):125-9. DOI: 10.1097/00004836-200009000-00007. View

18.

Scholl J, Pinheiro J, Riemann J . Helicobacter pylori-associated gastritis: does it play a role in functional dyspepsia?. Z Gastroenterol. 1995; 33(8):421-5. View

19.

Bodger K, Wyatt J, Heatley R . Variation in serum pepsinogens with severity and topography of Helicobacter pylori-associated chronic gastritis in dyspeptic patients referred for endoscopy. Helicobacter. 2001; 6(3):216-24. DOI: 10.1046/j.1523-5378.2001.00031.x. View

20.

Mera R, Fontham E, Bravo L, Bravo J, Piazuelo M, Camargo M . Long term follow up of patients treated for Helicobacter pylori infection. Gut. 2005; 54(11):1536-40. PMC: 1462952. DOI: 10.1136/gut.2005.072009. View