Erythrocyte Sodium/potassium ATPase Activity in Severe Preeclampsia

Overview

Journal J Perinatol

Specialty Gynecology & Obstetrics

Date 2009 Jan 23

PMID 19158804

Citations 5

Authors

C D Adair

G T Haupert Jr

H P Koh

Y Wang

J-C Veille

V Buckalew

Affiliations

Soon will be listed here.

Abstract

Objective: Elevated blood levels of endogenous digitalis-like factors (EDLF) may decrease erythrocyte sodium pump activity in preeclampsia. As the highest EDLF levels might be expected in severe preeclampsia, we investigated sodium pump activity in that group of patients.

Study Design: Erythrocyte sodium pump activity was determined by (86)Rubidium uptake (in nM per hour per 10(6) cells) in women with severe preeclampsia and those with normal pregnancies, matched for gestational age, and in healthy nonpregnant women (n=12 in each group). Differences between groups were analyzed by a two-sided Student t-test.

Result: Sodium pump activity was significantly increased in normotensive pregnancies as compared with normotensive non-pregnant women (81.4+/-8.4 vs 61.1+/-7.4, mean+/-s.d., p<0.05), and was decreased 43% in severe preeclamptic pregnancies as compared with normotensive pregnancies (46.4+/-14.1 vs 81.4+/-8.4, p<0.05).

Conclusion: Severe preeclampsia is associated with significantly lower erythrocyte sodium pump activity than normotensive pregnancy. These data suggest that plasma levels of a biologically active EDLF are elevated in patients with severe preeclampsia.

Citing Articles

Endogenous Digitalis-like Factors as a Key Molecule in the Pathophysiology of Pregnancy-Induced Hypertension and a Potential Therapeutic Target in Preeclampsia.

Socha M, Chmielewski J, Pietrus M, Wartega M Int J Mol Sci. 2023; 24(16).

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A New Method to Estimate Inhibition Percentage of Endogenous Digitalis in Patients with Pre-eclampsia.

Saad Al-Kawaz H, Yasser O, Mousa M Rep Biochem Mol Biol. 2022; 11(1):138-145.

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Natriuria and calciuria levels in preeclampsia: a cross-sectional study.

Gasnier R, Valerio E, Vettorazzi J, Martins-Costa S, Barros E, Geraldo Lopes Ramos J Sao Paulo Med J. 2013; 131(2):106-11.

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DigiFab interacts with endogenous cardiotonic steroids and reverses preeclampsia-induced Na/K-ATPase inhibition.

Ishkaraeva-Yakovleva V, Fedorova O, Solodovnikova N, Frolova E, Bzhelyansky A, Emelyanov I Reprod Sci. 2012; 19(12):1260-7.

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Interaction of Digibind with endogenous cardiotonic steroids from preeclamptic placentae.

Fedorova O, Tapilskaya N, Bzhelyansky A, Frolova E, Nikitina E, Reznik V J Hypertens. 2009; 28(2):361-6.

PMID: 19927009 PMC: 2809135. DOI: 10.1097/HJH.0b013e328333226c.

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