Activity-dependent Dendritic Release of BDNF and Biological Consequences

Overview

Journal Mol Neurobiol

Specialties Molecular Biology
Neurology

Date 2009 Jan 22

PMID 19156544

Citations 72

Authors

Nicola Kuczewski

Christophe Porcher

Volkmar Lessmann

Igor Medina

Jean-Luc Gaiarsa

Affiliations

Soon will be listed here.

Abstract

Network construction and reorganization is modulated by the level and pattern of synaptic activity generated in the nervous system. During the past decades, neurotrophins, and in particular brain-derived neurotrophic factor (BDNF), have emerged as attractive candidates for linking synaptic activity and brain plasticity. Thus, neurotrophin expression and secretion are under the control of activity-dependent mechanisms and, besides their classical role in supporting neuronal survival neurotrophins, modulate nearly all key steps of network construction from neuronal migration to experience-dependent refinement of local connections. In this paper, we provide an overview of recent findings showing that BDNF can serve as a target-derived messenger for activity-dependent synaptic plasticity and development at the single cell level.

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