Controlled Release of High Molecular Weight Hyaluronic Acid from Molecularly Imprinted Hydrogel Contact Lenses

Overview

Journal Pharm Res

Specialties Pharmacology
Pharmacy

Date 2009 Jan 22

PMID 19156504

Citations 31

Authors

Maryam Ali

Mark E Byrne

Affiliations

Soon will be listed here.

Abstract

Purpose: Current dry eye treatment includes delivering comfort agents to the eye via drops, but low bioavailability and multiple administration continues to be a barrier to effective treatment. There exists a significant unmet need for devices to treat dry eye and for more comfortable contact lenses.

Methods: Using molecular imprinting strategies with an analysis of biology, we have rationally designed and synthesized hydrogel contact lenses that can release hyaluronic acid (HA) at a controlled rate.

Results: Delayed release characteristics were significantly improved through biomimetic imprinting, as multiple functional monomers provided non-covalent complexation points within nelfilcon A gels without altering structural, mechanical, or optical properties. The diffusion coefficient of 1.2 million Dalton HA was controlled by varying the number and variety of functional monomers (increasing the variety lowered the HA diffusion coefficient 1.5 times more than single functional monomers, and 1.6 times more than nelfilcon A alone).

Conclusions: HA can be delivered from a daily disposable lens at a therapeutic rate of approximately 6 microg/h for 24 h. This is the first demonstration of imprinting a large molecular weight polymer within a hydrogel and the effect of imprinting on the reptation of the long chain macromolecule from the structure.

Citing Articles

How to Fabricate Hyaluronic Acid for Ocular Drug Delivery.

Kim M, Jung M, Lee D, Ahn S, Lee G, Park C Pharmaceutics. 2025; 16(12.

PMID: 39771582 PMC: 11680071. DOI: 10.3390/pharmaceutics16121604.

From Vision Correction to Drug Delivery: Unraveling the Potential of Therapeutic Contact Lens.

Saini A, Sharma M, Singh I, Swami R Curr Drug Deliv. 2024; 22(2):140-159.

PMID: 38213158 DOI: 10.2174/0115672018270396231213074746.

Characterization of the Molecular Weight of Hyaluronan in Eye Products Using a Novel Method of Size Exclusion High-Pressure Liquid Chromatography.

Nguyen L, Lin X, Verma S, Puri S, Hascall V, Gesteira T Transl Vis Sci Technol. 2023; 12(4):13.

PMID: 37052911 PMC: 10103721. DOI: 10.1167/tvst.12.4.13.

A Review on Dry Eye Disease Treatment: Recent Progress, Diagnostics, and Future Perspectives.

Mondal H, Kim H, Mohanto N, Jee J Pharmaceutics. 2023; 15(3).

PMID: 36986851 PMC: 10051136. DOI: 10.3390/pharmaceutics15030990.

Silica Hydrogels as Platform for Delivery of Hyaluronic Acid.

Parfenyuk E, Dolinina E Pharmaceutics. 2023; 15(1).

PMID: 36678706 PMC: 9864809. DOI: 10.3390/pharmaceutics15010077.

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