Rac1 GTPase: a "Rac" of All Trades

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2009 Jan 20

PMID 19151919

Citations 185

Authors

E E Bosco

J C Mulloy

Y Zheng

Affiliations

Soon will be listed here.

Abstract

Rac1, a member of the Rho family of GTPases, is an intracellular transducer known to regulate multiple signaling pathways that control cytoskeleton organization, transcription, and cell proliferation. Deregulated expression or activation patterns of Rac1 can result in aberrant cell signaling and numerous pathological conditions. Here, we highlight the physiological functions and signaling mechanisms of Rac1 and their relevance to disease.

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