Sleep Benefits Subsequent Hippocampal Functioning

Overview

Journal Nat Neurosci

Date 2009 Jan 20

PMID 19151712

Citations 96

Authors

Ysbrand D van der Werf

Ellemarije Altena

Menno M Schoonheim

Ernesto J Sanz-Arigita

Jose C Vis

Wim De Rijke

Eus J W van Someren

Affiliations

Soon will be listed here.

Abstract

Sleep before learning benefits memory encoding through unknown mechanisms. We found that even a mild sleep disruption that suppressed slow-wave activity and induced shallow sleep, but did not reduce total sleep time, was sufficient to affect subsequent successful encoding-related hippocampal activation and memory performance in healthy human subjects. Implicit learning was not affected. Our results suggest that the hippocampus is particularly sensitive to shallow, but intact, sleep.

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References

Isomura Y, Sirota A, Ozen S, Montgomery S, Mizuseki K, Henze D . Integration and segregation of activity in entorhinal-hippocampal subregions by neocortical slow oscillations. Neuron. 2006; 52(5):871-82. DOI: 10.1016/j.neuron.2006.10.023. View

Yoo S, Hu P, Gujar N, Jolesz F, Walker M . A deficit in the ability to form new human memories without sleep. Nat Neurosci. 2007; 10(3):385-92. DOI: 10.1038/nn1851. View

Stern C, Corkin S, Gonzalez R, Guimaraes A, Baker J, Jennings P . The hippocampal formation participates in novel picture encoding: evidence from functional magnetic resonance imaging. Proc Natl Acad Sci U S A. 1996; 93(16):8660-5. PMC: 38729. DOI: 10.1073/pnas.93.16.8660. View

Van Cauter E, Leproult R, Plat L . Age-related changes in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men. JAMA. 2000; 284(7):861-8. DOI: 10.1001/jama.284.7.861. View

Marshall L, Helgadottir H, Molle M, Born J . Boosting slow oscillations during sleep potentiates memory. Nature. 2006; 444(7119):610-3. DOI: 10.1038/nature05278. View

Ungerleider L, Haxby J . 'What' and 'where' in the human brain. Curr Opin Neurobiol. 1994; 4(2):157-65. DOI: 10.1016/0959-4388(94)90066-3. View

Lubenov E, Siapas A . Decoupling through synchrony in neuronal circuits with propagation delays. Neuron. 2008; 58(1):118-31. DOI: 10.1016/j.neuron.2008.01.036. View

McDermott C, Lahoste G, Chen C, Musto A, Bazan N, Magee J . Sleep deprivation causes behavioral, synaptic, and membrane excitability alterations in hippocampal neurons. J Neurosci. 2003; 23(29):9687-95. PMC: 6740462. View

Collins D, Pelletier J, Pare D . Slow and fast (gamma) neuronal oscillations in the perirhinal cortex and lateral amygdala. J Neurophysiol. 2001; 85(4):1661-72. DOI: 10.1152/jn.2001.85.4.1661. View

10.

Dolan R, Fletcher P . Dissociating prefrontal and hippocampal function in episodic memory encoding. Nature. 1997; 388(6642):582-5. DOI: 10.1038/41561. View

11.

Gron G, Bittner D, Schmitz B, Wunderlich A, Tomczak R, Riepe M . Variability in memory performance in aged healthy individuals: an fMRI study. Neurobiol Aging. 2003; 24(3):453-62. DOI: 10.1016/s0197-4580(02)00128-8. View