Targeted Delivery of Radioprotective Agents to Mitochondria

Overview

Journal Mol Interv

Specialty Molecular Biology

Date 2009 Jan 16

PMID 19144902

Citations 8

Authors

Irina Zabbarova

Anthony Kanai

Affiliations

Soon will be listed here.

Abstract

Adverse effects of ionizing radiation are mediated through reactive oxygen and nitrogen species. Mitochondria are the principal source of these species in the cell and play an important role in irradiation-induced apoptosis. The use of free radical scavengers and nitric oxide synthase inhibitors has proven to protect normal tissues and, in some cases, to sensitize tumor tissues to radiation damage. Dual molecules that combine radical-scavenging and NOS-inhibitory functions may be particularly effective. Drugging strategies that target mitochondria can enhance the effectiveness of such agents, in comparison to systemic administration, and circumvent side effects.

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