Ziziphus Jujuba Extract for the Treatment of Chronic Idiopathic Constipation: a Controlled Clinical Trial

Overview

Journal Digestion

Specialty Gastroenterology

Date 2009 Jan 15

PMID 19142004

Citations 14

Authors

Timna Naftali

Haya Feingelernt

Yevgeni Lesin

Ariela Rauchwarger

Fred Meir Konikoff

Affiliations

Soon will be listed here.

Abstract

Purpose: To investigate the safety and efficacy of an extract of Ziziphus jujuba for chronic constipation.Constipated patients received liquid Z. jujuba or placebo for 12 weeks. Subjects completed questionnaires, a visual analog scale and transit time (TT) tests before and after treatment.

Results: Of 37 patients with a prolonged TT, 18 received the study drug and 19 a placebo. Two (12%) of the study and 16 (84%) of the control group dropped out due to severe constipation. The TT decreased from 12.2 particles for the study group to 3 particles at week 11. Symptom severity ratings decreased from 6 and 6.2 to 2 and 5, and the quality of life score improved from 1.9 and 2.3 to 1.3 and 1.4 in the study and control groups, respectively.

Conclusion: Z. jujuba extract is an effective and safe treatment for chronic constipation.

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