Prevention of Allograft Rejection by Amplification of Foxp3(+)CD4(+)CD25(+) Regulatory T Cells

Overview

Journal Transl Res

Publisher Elsevier

Specialty Pathology

Date 2009 Jan 14

PMID 19138650

Citations 7

Authors

Guliang Xia

Malathi Shah

Xunrong Luo

Affiliations

Soon will be listed here.

Abstract

CD4(+)CD25(+) T cells were identified originally as potent suppressors of autoimmunity and were later termed "natural regulatory T cells" or nTreg cells. Subsequently, a transcription factor called forkhead box protein 3 (Foxp3) was identified to be a critical regulator for Treg differentiation and function. Foxp3(+)CD4(+)CD25(+) Treg cells have been increasingly documented to suppress allograft rejection and to mediate allograft tolerance in transplantation. In this article, the authors review current approaches for amplification of allo-specific Foxp3(+)CD4(+)CD25(+) Treg cells for prevention of allograft rejection and induction of allo-specific transplant tolerance.

Citing Articles

Fas, FasL and Foxp3 gene expression in post-liver transplant autoimmune hepatitis patients with and without acute rejection.

Shams K, Kalantar K, Karimi M, Nasiri M, Afshari A, Amirghofran Z Clin Exp Hepatol. 2019; 5(2):103-108.

PMID: 31501785 PMC: 6728859. DOI: 10.5114/ceh.2019.85076.

Alloreactive Regulatory T Cells Allow the Generation of Mixed Chimerism and Transplant Tolerance.

Ruiz P, Maldonado P, Hidalgo Y, Sauma D, Rosemblatt M, Bono M Front Immunol. 2015; 6:596.

PMID: 26635810 PMC: 4655502. DOI: 10.3389/fimmu.2015.00596.

Prevention of acute liver allograft rejection by IL-10-engineered mesenchymal stem cells.

Niu J, Yue W, Song Y, Zhang Y, Qi X, Wang Z Clin Exp Immunol. 2014; 176(3):473-84.

PMID: 24527865 PMC: 4008992. DOI: 10.1111/cei.12283.

Whole-body imaging of adoptively transferred T cells using magnetic resonance imaging, single photon emission computed tomography and positron emission tomography techniques, with a focus on regulatory T cells.

Leech J, Sharif-Paghaleh E, Maher J, Livieratos L, Lechler R, Mullen G Clin Exp Immunol. 2013; 172(2):169-77.

PMID: 23574314 PMC: 3628320. DOI: 10.1111/cei.12087.

Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance.

Kendal A, Chen Y, Regateiro F, Ma J, Adams E, Cobbold S J Exp Med. 2011; 208(10):2043-53.

PMID: 21875958 PMC: 3182049. DOI: 10.1084/jem.20110767.

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