Melanoma Biology and the Promise of Zebrafish

Overview

Journal Zebrafish

Date 2009 Jan 13

PMID 19133823

Citations 22

Authors

Craig J Ceol

Yariv Houvras

Richard M White

Leonard I Zon

Affiliations

Soon will be listed here.

Abstract

Advantageous organismal and technical attributes of the zebrafish are being increasingly applied to study cancer biology. Along with other tumor models, zebrafish that develop melanomas have been generated. In both genetics and phenotype, zebrafish melanomas are strikingly similar to their human counterparts. For this reason, studies in the zebrafish are poised to make significant contributions to melanoma biology. In this review, we summarize important features of human melanoma and discuss how the zebrafish can be used to address many questions that remain unanswered about this devastating disease.

Citing Articles

Zebrafish in dermatology: a comprehensive review of their role in investigating abnormal skin pigmentation mechanisms.

Qu J, Yan M, Fang Y, Zhao J, Xu T, Liu F Front Physiol. 2023; 14:1296046.

PMID: 38074315 PMC: 10702362. DOI: 10.3389/fphys.2023.1296046.

Canonical Wnt and TGF-β/BMP signaling enhance melanocyte regeneration but suppress invasiveness, migration, and proliferation of melanoma cells.

Katkat E, Demirci Y, Heger G, Karagulle D, Papatheodorou I, Brazma A Front Cell Dev Biol. 2023; 11:1297910.

PMID: 38020918 PMC: 10679360. DOI: 10.3389/fcell.2023.1297910.

Anti-Melanogenic Potential of Natural and Synthetic Substances: Application in Zebrafish Model.

Ferreira A, de Souza A, Koga R, Sena I, Matos M, Tomazi R Molecules. 2023; 28(3).

PMID: 36770722 PMC: 9920495. DOI: 10.3390/molecules28031053.

ADAMTS13 protease or lack of von Willebrand factor protects irradiation and melanoma-induced thrombotic microangiopathy in zebrafish.

Zheng L, Cao L, Zheng X J Thromb Haemost. 2022; 20(10):2270-2283.

PMID: 35894519 PMC: 9641623. DOI: 10.1111/jth.15820.

Inhibition of the STAT3 Signaling Pathway Contributes to the Anti-Melanoma Activities of Shikonin.

Cao H, Liu D, Lai Y, Chen Y, Yu L, Shao M Front Pharmacol. 2020; 11:748.

PMID: 32536866 PMC: 7267064. DOI: 10.3389/fphar.2020.00748.

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