Regulation of Inositol 1,4,5-trisphosphate-induced Ca2+ Release by Reversible Phosphorylation and Dephosphorylation

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 2009 Jan 10

PMID 19133301

Citations 84

Authors

Veerle Vanderheyden

Benoit Devogelaere

Ludwig Missiaen

Humbert De Smedt

Geert Bultynck

Jan B Parys

Affiliations

Soon will be listed here.

Abstract

The inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) is a universal intracellular Ca2+-release channel. It is activated after cell stimulation and plays a crucial role in the initiation and propagation of the complex spatio-temporal Ca2+ signals that control cellular processes as different as fertilization, cell division, cell migration, differentiation, metabolism, muscle contraction, secretion, neuronal processing, and ultimately cell death. To achieve these various functions, often in a single cell, exquisite control of the Ca2+ release is needed. This review aims to highlight how protein kinases and protein phosphatases can interact with the IP3R or with associated proteins and so provide a large potential for fine tuning the Ca2+-release activity and for creating efficient Ca2+ signals in subcellular microdomains.

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