REM Sleep Deprivation Reduces Auditory Evoked Inhibition of Dorsolateral Pontine Neurons

Overview

Journal Brain Res

Specialty Neurology

Date 1991 Jun 28

PMID 1913194

Citations 6

Authors

B N Mallick

H M Fahringer

M F Wu

J M Siegel

Affiliations

Soon will be listed here.

Abstract

In many dorsolateral pontine neurons, auditory stimulation produces an initial excitation followed by a sustained inhibition. We now report that rapid eye movement (REM) sleep deprivation, for periods of from 22-48 h, reduced this auditory evoked inhibition of unit discharge. Inhibition returned to baseline levels after recovery REM sleep. Prior work indicates that the auditory evoked inhibition seen in noradrenergic cells in this region is partially mediated by norepinephrine. We hypothesize that the reduction in inhibition that we see is a consequence of either downregulation/desensitization of norepinephrine receptors or reduced norepinephrine release resulting from REM sleep deprivation.

Citing Articles

REM Sleep Loss-Induced Elevated Noradrenaline Plays a Significant Role in Neurodegeneration: Synthesis of Findings to Propose a Possible Mechanism of Action from Molecule to Patho-Physiological Changes.

Giri S, Mehta R, Mallick B Brain Sci. 2024; 14(1).

PMID: 38275513 PMC: 10813190. DOI: 10.3390/brainsci14010008.

REM sleep loss-induced elevated noradrenaline could predispose an individual to psychosomatic disorders: a review focused on proposal for prediction, prevention, and personalized treatment.

Mehta R, Giri S, Mallick B EPMA J. 2020; 11(4):529-549.

PMID: 33240449 PMC: 7680499. DOI: 10.1007/s13167-020-00222-1.

Relevance of deprivation studies in understanding rapid eye movement sleep.

Mehta R, Khan S, Mallick B Nat Sci Sleep. 2018; 10:143-158.

PMID: 29881316 PMC: 5983021. DOI: 10.2147/NSS.S140621.

Enhanced emotional reactivity after selective REM sleep deprivation in humans: an fMRI study.

Rosales-Lagarde A, Armony J, Del Rio-Portilla Y, Trejo-Martinez D, Conde R, Corsi-Cabrera M Front Behav Neurosci. 2012; 6:25.

PMID: 22719723 PMC: 3376727. DOI: 10.3389/fnbeh.2012.00025.

Mechanism of noradrenaline-induced stimulation of Na-K ATPase activity in the rat brain: implications on REM sleep deprivation-induced increase in brain excitability.

Mallick B, Singh S, Singh A Mol Cell Biochem. 2009; 336(1-2):3-16.

PMID: 19823772 DOI: 10.1007/s11010-009-0260-9.

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