Reduced Behavioral Response to Gonadal Hormones in Mice Shipped During the Peripubertal/adolescent Period

Overview

Journal Endocrinology

Publisher Oxford University Press

Specialty Endocrinology

Date 2009 Jan 10

PMID 19131570

Citations 50

Authors

Julie Laroche

Lauren Gasbarro

James P Herman

Jeffrey D Blaustein

Affiliations

Soon will be listed here.

Abstract

Animals shipped from commercial suppliers to laboratories are exposed to a wide variety of stressors. Female C57Bl6/J mice shipped during the peripubertal/adolescent period (6 wk old) display lower levels of female sexual behavior in response to estradiol and progesterone injections after ovariectomy when tested in adulthood than female mice shipped in adulthood (12 wk old). These shipping-induced reductions in female sexual behavior appear to be limited to a vulnerable period around the time of puberty. Likewise, male mice shipped at 6 wk of age express lower levels of masculine sexual behavior in response to testosterone treatment as adults than do mice shipped when 12 wk old. RIA of corticosterone levels in response to behavior testing revealed that, upon first exposure to testing, mice shipped at 6 wk of age have reduced corticosterone levels. These results suggest that during the peripubertal/adolescent period, mice of both sexes are susceptible to the effects of stressors associated with shipping. Furthermore, they suggest that stress during this period has enduring, negative influences on behavioral responses to estradiol and progesterone in females and to testosterone in males, and it induces changes in response of the hypothalamic-pituitary-adrenal axis. These results suggest that age at shipping is a critical variable that may influence many endocrinological studies, and they suggest that the peripubertal/adolescent period is a period of vulnerability to some stressors.

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References

Herrenkohl L, Politch J . Effects of prenatal stress on the estrous cycle of female offspring as adults. Experientia. 1978; 34(9):1240-1. DOI: 10.1007/BF01922982. View

Barraclough C, Gorski R . Studies on mating behavior in the androgen-sterilized female rat in relation to the hypothalamic regulation of sexual behaviour. J Endocrinol. 1962; 25:175-82. DOI: 10.1677/joe.0.0250175. View

Zielinski W, Vandenbergh J, Montano M . Effects of social stress and intrauterine position on sexual phenotype in wild-type house mice (Mus musculus). Physiol Behav. 1991; 49(1):117-23. DOI: 10.1016/0031-9384(91)90241-f. View

Stewart J, Kolb B . The effects of neonatal gonadectomy and prenatal stress on cortical thickness and asymmetry in rats. Behav Neural Biol. 1988; 49(3):344-60. DOI: 10.1016/s0163-1047(88)90354-8. View

Paris A, Ramaley J . Effects of short-term stress upon fertility, I. Before puberty. Fertil Steril. 1973; 24(7):540-5. DOI: 10.1016/s0015-0282(16)39795-3. View

Armario A, Hernandez J, Bluethmann H, Hidalgo J . IL-6 deficiency leads to increased emotionality in mice: evidence in transgenic mice carrying a null mutation for IL-6. J Neuroimmunol. 1999; 92(1-2):160-9. DOI: 10.1016/s0165-5728(98)00199-4. View

Sisk C, Zehr J . Pubertal hormones organize the adolescent brain and behavior. Front Neuroendocrinol. 2005; 26(3-4):163-74. DOI: 10.1016/j.yfrne.2005.10.003. View

Bowman R, MacLusky N, Sarmiento Y, Frankfurt M, Gordon M, Luine V . Sexually dimorphic effects of prenatal stress on cognition, hormonal responses, and central neurotransmitters. Endocrinology. 2004; 145(8):3778-87. DOI: 10.1210/en.2003-1759. View

Phoenix C, Goy R, GERALL A, Young W . Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig. Endocrinology. 1959; 65:369-82. DOI: 10.1210/endo-65-3-369. View

10.

Romeo R, Lee S, McEwen B . Differential stress reactivity in intact and ovariectomized prepubertal and adult female rats. Neuroendocrinology. 2005; 80(6):387-93. DOI: 10.1159/000084203. View

11.

Spinedi E, Chisari A, Pralong F, Gaillard R . Sexual dimorphism in the mouse hypothalamic-pituitary-adrenal axis function after endotoxin and insulin stresses during development. Neuroimmunomodulation. 1997; 4(2):77-83. DOI: 10.1159/000097324. View

12.

McCormick C, Robarts D, Gleason E, Kelsey J . Stress during adolescence enhances locomotor sensitization to nicotine in adulthood in female, but not male, rats. Horm Behav. 2004; 46(4):458-66. DOI: 10.1016/j.yhbeh.2004.05.004. View

13.

Tuli J, Smith J, Morton D . Stress measurements in mice after transportation. Lab Anim. 1995; 29(2):132-8. DOI: 10.1258/002367795780740249. View

14.

Stephens D, Adams C . Observations on the effects of vibration stress and sound on pregnancy, parturition and respiration in the rabbit. Lab Anim. 1982; 16(4):341-7. DOI: 10.1258/002367782780935940. View

15.

McCormick C, Robarts D, Kopeikina K, Kelsey J . Long-lasting, sex- and age-specific effects of social stressors on corticosterone responses to restraint and on locomotor responses to psychostimulants in rats. Horm Behav. 2005; 48(1):64-74. DOI: 10.1016/j.yhbeh.2005.01.008. View

16.

Romeo R, Bellani R, Karatsoreos I, Chhua N, Vernov M, Conrad C . Stress history and pubertal development interact to shape hypothalamic-pituitary-adrenal axis plasticity. Endocrinology. 2006; 147(4):1664-74. DOI: 10.1210/en.2005-1432. View

17.

Schulz K, Richardson H, Romeo R, Morris J, Lookingland K, Sisk C . Medial preoptic area dopaminergic responses to female pheromones develop during puberty in the male Syrian hamster. Brain Res. 2003; 988(1-2):139-45. DOI: 10.1016/s0006-8993(03)03358-4. View

18.

Wallace M . Effects of stress due to deprivation and transport in different genotypes of house mouse. Lab Anim. 1976; 10(3):335-47. DOI: 10.1258/002367776781035260. View

19.

Yehuda R, Giller E, Southwick S, Lowy M, Mason J . Hypothalamic-pituitary-adrenal dysfunction in posttraumatic stress disorder. Biol Psychiatry. 1991; 30(10):1031-48. DOI: 10.1016/0006-3223(91)90123-4. View

20.

Landi M, KREIDER J, Lang C, Bullock L . Effects of shipping on the immune function in mice. Am J Vet Res. 1982; 43(9):1654-7. View