Kinetic Complexity of the Global Response to Glucocorticoid Receptor Action

Overview

Journal Endocrinology

Publisher Oxford University Press

Specialty Endocrinology

Date 2009 Jan 10

PMID 19131569

Citations 63

Authors

Sam John

Thomas A Johnson

Myong-Hee Sung

Simon C Biddie

Saskia Trump

Christine A Koch-Paiz

Sean R Davis

Robert Walker

Paul S Meltzer

Gordon L Hager

Affiliations

Soon will be listed here.

Abstract

We have characterized the kinetic response of gene targets throughout the murine genome to transcriptional modulation by the glucocorticoid receptor (GR). In contrast to a model in which multiple genes are either repressed or activated during the GR response, the vast majority of responsive genes are subject to complex regulation profiles, frequently with alternate activation and repression phases. We also observe that GR binding at response elements does not always correlate with the target gene response profile. Thus, the cellular response to GR stimulation involves a highly orchestrated series of regulatory actions and not simply a binary response to hormone.

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