Serum IL-6 Levels Are Associated with Significant Coronary Stenosis in Cardiovascularly Asymptomatic Inner-city Black Adults in the US

Overview

Journal Inflamm Res

Specialties Allergy & Immunology
Pathology

Date 2009 Jan 9

PMID 19130178

Citations 11

Authors

S Lai

E K Fishman

H Lai

H Pannu

B Detrick

Affiliations

Soon will be listed here.

Abstract

Objectives And Design: The objective of this study was to explore whether increased levels of inflammatory cytokines are associated with the risk of clinically silent coronary artery disease.

Subjects: Three-hundred-fifty-six black adults aged 25-54 residing in inner city of Baltimore, Maryland, United States were included in this study.

Methods: Sociodemographics were assessed as were lipid profiles, IL-6, tumor necrosis factor-alpha (TNF-alpha), soluble intercellular adhesion molecule-1 (sICAM-1), and high-sensitivity C-reactive protein (hs-CRP) levels. Computed tomography (CT) coronary angiography was performed.

Results: Coronary calcification was identified in 22.5 % participants and 14 % had significant (>or=50 %) coronary stenosis. Multiple logistic regression analyses suggested that IL-6 levels were independently associated with the presence of coronary calcification and significant coronary stenosis, while TNF-alpha, sICAM-1 and hs-CRP levels were not.

Conclusions: This study underscores a critical role for IL-6 in atherosclerosis and suggests that IL-6 may be a marker for significant coronary stenosis in cardiovascularly asymptomatic individuals.

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