Stimulation of Glucagon and Inhibition of Insulin Secretion Evoked from Carotid Baroreceptors

Overview

Journal Experientia

Specialty Science

Date 1977 Feb 15

PMID 191288

Citations 3

Authors

J Jarhult

J J Holst

Affiliations

Soon will be listed here.

Abstract

The influence from carotid baroreceptors on portal immuno-reactive glucagon and insulin levels and on arterial plasma glucose concentration was studied in vagotomized cats by sectioning of the sinus nerves. Such a complete elimination of the afferent baroreceptor discharge caused a prompt and pronounced increase in the glucose and glucagon levels, whereas the insulin concentration significantly decreased. The role of vascular barorecptors in the hyperglycemic response to hemorrhage is discussed.

Citing Articles

The effect of intraportal and peripheral infusions of glucagon on insulin and glucose concentrations and glucose tolerance in normal man.

Holst J, Madsen O, Knop J, Schmidt A Diabetologia. 1977; 13(5):487-90.

PMID: 908472 DOI: 10.1007/BF01234501.

The functional importance of sympathetic nerves to the liver and endocrine pancreas.

Jarhult J, Falck B, Ingemansson S, Nobin A Ann Surg. 1979; 189(1):96-100.

PMID: 365113 PMC: 1396948. DOI: 10.1097/00000658-197901000-00018.

The role of the adrenergic innervation to the pancreatic islets in the control of insulin release during exercise in man.

Jarhult J, Holst J Pflugers Arch. 1979; 383(1):41-5.

PMID: 230455 DOI: 10.1007/BF00584473.

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