Ethanol for Cardiac Ischemia: the Role of Protein Kinase C

Overview

Journal Ther Adv Cardiovasc Dis

Publisher Sage Publications

Specialties Cardiology & Vascular Diseases
Pharmacology

Date 2009 Jan 7

PMID 19124442

Citations 7

Authors

Eric N Churchill

Marie-Helene Disatnik

Grant R Budas

Daria Mochly-Rosen

Affiliations

Soon will be listed here.

Abstract

The physiological effects of ethanol are dependent upon the amount and duration of consumption. Chronic excessive consumption can lead to diseases such as liver cirrhosis, and cardiac arrhythmias, while chronic moderate consumption can have therapeutic effects on the cardiovascular system. Recently, it has also been observed that acute administration of ethanol to animals prior to an ischemic event provides significant protection to the heart. This review focuses on the different modalities of chronic vs. acute ethanol consumption and discusses recent evidence for a protective effect of acute ethanol exposure and the possible use of ethanol as a therapeutic agent.

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