Models for Chromosomal Replication-independent Non-B DNA Structure-induced Genetic Instability

Overview

Journal Mol Carcinog

Specialties Molecular Biology
Oncology

Date 2009 Jan 6

PMID 19123200

Citations 32

Authors

Guliang Wang

Karen M Vasquez

Affiliations

Soon will be listed here.

Abstract

Regions of genomic DNA containing repetitive nucleotide sequences can adopt a number of different structures in addition to the canonical B-DNA form: many of these non-B DNA structures are causative factors in genetic instability and human disease. Although chromosomal DNA replication through such repetitive sequences has been considered a major cause of non-B form DNA structure-induced genetic instability, it is also observed in non-proliferative tissues. In this review, we discuss putative mechanisms responsible for the mutagenesis induced by non-B DNA structures in the absence of chromosomal DNA replication.

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