The HLH Protein Extramacrochaetae is Required for R7 Cell and Cone Cell Fates in the Drosophila Eye

Overview

Journal Dev Biol

Publisher Elsevier

Specialties Biology
Reproductive Medicine

Date 2009 Jan 3

PMID 19118542

Citations 33

Authors

Abhishek Bhattacharya

Nicholas E Baker

Affiliations

Soon will be listed here.

Abstract

Notch signaling is one of the most important pathways in development and homeostasis, and is altered in multiple pathologies. Study of Drosophila eye development shows that Notch signaling depends on the HLH protein Extramacrochaetae. Null mutant clones show that extramacrochaetae is required for multiple aspects of eye development that depend on Notch signaling, including morphogenetic furrow progression, differentiation of R4, R7 and cone cell types, and rotation of ommatidial clusters. Detailed analysis of R7 and cone cell specification reveals that extramacrochaetae acts cell autonomously and epistatically to Notch, and is required for normal expression of bHLH genes encoded by the E(spl)-C which are effectors of most Notch signaling. A model is proposed in which Extramacrochaetae acts in parallel to or as a feed-forward regulator of the E(spl)-Complex to promote Notch signaling in particular cellular contexts.

Citing Articles

Extramacrochaetae regulates Notch signaling in the eye through non-apoptotic caspase activity.

Nair S, Baker N Elife. 2024; 12.

PMID: 39564985 PMC: 11578588. DOI: 10.7554/eLife.91988.

Extramacrochaetae regulates Notch signaling in the eye through non-apoptotic caspase activity.

Nair S, Baker N bioRxiv. 2024; .

PMID: 39131389 PMC: 11312471. DOI: 10.1101/2023.10.04.560841.

The Id protein Extramacrochaetae restrains the E protein Daughterless to regulate Notch, Rap1, and Sevenless within the R7 equivalence group of the Drosophila eye.

Reddy Onteddu V, Bhattacharya A, Baker N Biol Open. 2024; 13(8).

PMID: 39041866 PMC: 11360143. DOI: 10.1242/bio.060124.

Semper's cells in the insect compound eye: Insights into ocular form and function.

Charlton-Perkins M, Friedrich M, Cook T Dev Biol. 2021; 479:126-138.

PMID: 34343526 PMC: 8410683. DOI: 10.1016/j.ydbio.2021.07.015.

Variation in Pleiotropic Hub Gene Expression Is Associated with Interspecific Differences in Head Shape and Eye Size in Drosophila.

Buchberger E, Bilen A, Ayaz S, Salamanca D, Heras C, Niksic A Mol Biol Evol. 2021; 38(5):1924-1942.

PMID: 33386848 PMC: 8097299. DOI: 10.1093/molbev/msaa335.

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