Poultry-associated Salmonella Enterica Subsp. Enterica Serovar 4,12:d:- Reveals High Clonality and a Distinct Pathogenicity Gene Repertoire

Overview

Journal Appl Environ Microbiol

Specialties Environmental Health
Microbiology

Date 2008 Dec 31

PMID 19114530

Citations 16

Authors

Stephan Huehn

Cornelia Bunge

Ernst Junker

Reiner Helmuth

Burkhard Malorny

Affiliations

Soon will be listed here.

Abstract

A European baseline survey during the years 2005 and 2006 has revealed that the monophasic Salmonella enterica subsp. enterica serovar 4,12:d:- was, with a prevalence of 23.6%, the most frequently isolated serovar in German broiler flocks. In Denmark and the United Kingdom, its serovar prevalences were 15.15% and 2.8%, respectively. Although poultry is a major source of human salmonellosis, serovar 4,12:d:- is rarely isolated in humans (approximately 0.09% per year). Molecular typing studies using pulsed-field gel electrophoresis and DNA microarray analysis show that the serovar is highly clonal and lacks genes with known contributions to pathogenicity. In contrast to other poultry-associated serovars, all strains were susceptible to 17 antimicrobial agents tested and did not encode any resistance determinant. Furthermore, serovar 4,12:d:- lacked the genes involved in galactonate metabolism and in the glycolysis and glyconeogenesis important for energy production in the cells. The conclusion of the study is that serovar 4,12:d:- seems to be primarily adapted to broilers and therefore causes only rare infections in humans.

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