Genetic Analysis of the Vitamin D Receptor Gene in Two Epithelial Cancers: Melanoma and Breast Cancer Case-control Studies

Overview

Journal BMC Cancer

Publisher Biomed Central

Specialty Oncology

Date 2008 Dec 25

PMID 19105801

Citations 26

Authors

Eva Barroso

Lara P Fernandez

Roger L Milne

Guillermo Pita

Elena Sendagorta

Uxua Floristan

Marta Feito

Jose A Aviles

Manuel Martin-Gonzalez

Jose I Arias

Pilar Zamora

Monserrat Blanco

Pablo Lazaro

Javier Benitez

Gloria Ribas

Affiliations

Soon will be listed here.

Abstract

Background: Vitamin D serum levels have been found to be related to sun exposure and diet, together with cell differentiation, growth control and consequently, cancer risk. Vitamin D receptor (VDR) genotypes may influence cancer risk; however, no epidemiological studies in sporadic breast cancer (BC) or malignant melanoma (MM) have been performed in a southern European population. In this study, the VDR gene has been evaluated in two epithelial cancers BC and MM.

Methods: We have conducted an analysis in 549 consecutive and non-related sporadic BC cases and 556 controls, all from the Spanish population, and 283 MM cases and 245 controls. Genotyping analyses were carried out on four putatively functional SNPs within the VDR gene.

Results: An association with the minor allele A of the non-synonymous SNP rs2228570 (rs10735810, FokI, Met1Thr) was observed for BC, with an estimated odds ratio (OR) of 1.26 (95% CI = 1.02-1.57; p = 0.036). The synonymous variant rs731236 (TaqI) appeared to be associated with protection from BC (OR = 0.80, 95%CI = 0.64-0.99; p = 0.047). No statistically significant associations with MM were observed for any SNP. Nevertheless, sub-group analyses revealed an association between rs2228570 (FokI) and absence of childhood sunburns (OR = 0.65, p = 0.003), between the 3'utr SNP rs739837 (BglI) and fair skin (OR = 1.31, p = 0.048), and between the promoter SNP rs4516035 and the more aggressive tumour location in head-neck and trunk (OR = 1.54, p = 0.020).

Conclusion: In summary, we observed associations between SNPs in the VDR gene and BC risk, and a comprehensive analysis using clinical and tumour characteristics as outcome variables has revealed potential associations with MM. These associations required confirmation in independent studies.

Citing Articles

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The relationship between single nucleotide polymorphisms and skin cancer susceptibility: A systematic review and network meta-analysis.

Zhang L, Pozsgai E, Song Y, Macharia J, Alfatafta H, Zheng J Front Oncol. 2023; 13:1094309.

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FokI polymorphism of Vitamin D receptor gene and deficiency of serum Vitamin D increases the risk of breast cancer in North Indian women.

Chakraborty M, Arora M, Ramteke A, Yadav V, Naaz H, Muntakhab M Endocrine. 2023; 81(1):168-174.

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Vitamin D receptor polymorphisms and melanoma.

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