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Transdermal Nitrate Therapy: Bioavailability During Exercise Increases Transiently After the Daily Change of Patch

Overview
Journal Br J Clin Pharmacol
Specialty Pharmacology
Date 1991 May 1
PMID 1909540
Citations 10
Authors
K Gjesdal
T O Klemsdal
E O Rykke
J E. Bredesen
Affiliations
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Abstract

Ten volunteers carried a 10 mg 24 h -1 transdermal glyceryl trinitrate (GTN) patch for 24 h before moderate exercise. Plasma GTN-concentration increased significantly (P less than 0.05) by 19% to peak value at 15 min. Two hours after patch renewal repeat exercise increased GTN concentration by 56% (P less than 0.001). The two nitrate-concentration curves differed significantly (P less than 0.0001). Thus, change of patch augmented nitrate availability during exercise.

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References
1.
Barkve T, Langseth-Manrique K, Bredesen J, Gjesdal K . Increased uptake of transdermal glyceryl trinitrate during physical exercise and during high ambient temperature. Am Heart J. 1986; 112(3):537-41. DOI: 10.1016/0002-8703(86)90518-1. View
2.
Heidemann R, Beckenbauer C, Woodcock B . Effect of posture on glyceryl trinitrate plasma concentrations following transdermal application. Br J Clin Pharmacol. 1987; 23(2):246-7. PMC: 1386078. DOI: 10.1111/j.1365-2125.1987.tb03039.x. View
3.
Weber S, de Lauture D, Rey E, Darragon T, Severins J, Ditisheim A . The effects of moderate sustained exercise on the pharmacokinetics of nitroglycerine. Br J Clin Pharmacol. 1987; 23(1):103-5. PMC: 1386149. DOI: 10.1111/j.1365-2125.1987.tb03018.x. View
4.
Curry S, Kwon H . Influence of posture on plasma nitroglycerin. Br J Clin Pharmacol. 1985; 19(3):403-4. PMC: 1463739. DOI: 10.1111/j.1365-2125.1985.tb02661.x. View
5.
Metelitsa V, Martsevich SYu , Piotrovskii V, Ryabokon O, Blagodatskikh S . New transdermal and transmucosal nitroglycerin delivery systems in patients with ischaemic heart disease. Eur J Clin Pharmacol. 1987; 32(1):5-10. DOI: 10.1007/BF00609950. View