NK Cells in HIV-1 Infection: Evidence for Their Role in the Control of HIV-1 Infection

Overview

Journal J Intern Med

Specialty General Medicine

Date 2008 Dec 20

PMID 19093958

Citations 97

Authors

G Alter

M Altfeld

Affiliations

Soon will be listed here.

Abstract

Increasing evidence supports the notion that the innate immune response, and in particular, natural killer cells play a central role in determining the quality of the host immune response to infection. In this review we highlight recent evidence that suggests that NK cells influence the clinical fate of HIV-infected individuals.

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References

Schwartz O, Marechal V, Le Gall S, Lemonnier F, Heard J . Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein. Nat Med. 1996; 2(3):338-42. DOI: 10.1038/nm0396-338. View

Martin M, Gao X, Lee J, Nelson G, Detels R, Goedert J . Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat Genet. 2002; 31(4):429-34. DOI: 10.1038/ng934. View

Gumperz J, Barber L, Valiante N, Percival L, Phillips J, Lanier L . Conserved and variable residues within the Bw4 motif of HLA-B make separable contributions to recognition by the NKB1 killer cell-inhibitory receptor. J Immunol. 1997; 158(11):5237-41. View

COHEN G, Gandhi R, Davis D, Mandelboim O, Chen B, Strominger J . The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells. Immunity. 1999; 10(6):661-71. DOI: 10.1016/s1074-7613(00)80065-5. View

Lodoen M, Lanier L . Viral modulation of NK cell immunity. Nat Rev Microbiol. 2004; 3(1):59-69. DOI: 10.1038/nrmicro1066. View

Walzer T, Dalod M, Robbins S, Zitvogel L, Vivier E . Natural-killer cells and dendritic cells: "l'union fait la force". Blood. 2005; 106(7):2252-8. DOI: 10.1182/blood-2005-03-1154. View

Yokoyama W, Kim S, French A . The dynamic life of natural killer cells. Annu Rev Immunol. 2004; 22:405-29. DOI: 10.1146/annurev.immunol.22.012703.104711. View

Lifson J, Nowak M, Goldstein S, Rossio J, Kinter A, Vasquez G . The extent of early viral replication is a critical determinant of the natural history of simian immunodeficiency virus infection. J Virol. 1997; 71(12):9508-14. PMC: 230257. DOI: 10.1128/JVI.71.12.9508-9514.1997. View

Dunn C, Brunetto M, Reynolds G, Christophides T, Kennedy P, Lampertico P . Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage. J Exp Med. 2007; 204(3):667-80. PMC: 2137916. DOI: 10.1084/jem.20061287. View

10.

Johansson S, Johansson M, Rosmaraki E, Vahlne G, Mehr R, Salmon-Divon M . Natural killer cell education in mice with single or multiple major histocompatibility complex class I molecules. J Exp Med. 2005; 201(7):1145-55. PMC: 2213126. DOI: 10.1084/jem.20050167. View

11.

Moretta A, Bottino C, Mingari M, Biassoni R, Moretta L . What is a natural killer cell?. Nat Immunol. 2001; 3(1):6-8. DOI: 10.1038/ni0102-6. View

12.

Moretta L, Moretta A . Unravelling natural killer cell function: triggering and inhibitory human NK receptors. EMBO J. 2003; 23(2):255-9. PMC: 1271745. DOI: 10.1038/sj.emboj.7600019. View

13.

Gerosa F, Baldani-Guerra B, Nisii C, Marchesini V, Carra G, Trinchieri G . Reciprocal activating interaction between natural killer cells and dendritic cells. J Exp Med. 2002; 195(3):327-33. PMC: 2193595. DOI: 10.1084/jem.20010938. View

14.

Mandelboim O, Reyburn H, Sheu E, Vales-Gomez M, Davis D, Pazmany L . The binding site of NK receptors on HLA-C molecules. Immunity. 1997; 6(3):341-50. DOI: 10.1016/s1074-7613(00)80336-2. View

15.

Allen T, Altfeld M, Geer S, Kalife E, Moore C, OSullivan K . Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution. J Virol. 2005; 79(21):13239-49. PMC: 1262562. DOI: 10.1128/JVI.79.21.13239-13249.2005. View

16.

Corral L, Hanke T, VANCE R, Cado D, Raulet D . NK cell expression of the killer cell lectin-like receptor G1 (KLRG1), the mouse homolog of MAFA, is modulated by MHC class I molecules. Eur J Immunol. 2000; 30(3):920-30. DOI: 10.1002/1521-4141(200003)30:3<920::AID-IMMU920>3.0.CO;2-P. View

17.

Fischer L, Penack O, Gentilini C, Nogai A, Muessig A, Thiel E . The anti-lymphoma effect of antibody-mediated immunotherapy is based on an increased degranulation of peripheral blood natural killer (NK) cells. Exp Hematol. 2006; 34(6):753-9. DOI: 10.1016/j.exphem.2006.02.015. View

18.

Salcedo M, Andersson M, Lemieux S, Van Kaer L, Chambers B, Ljunggren H . Fine tuning of natural killer cell specificity and maintenance of self tolerance in MHC class I-deficient mice. Eur J Immunol. 1998; 28(4):1315-21. DOI: 10.1002/(SICI)1521-4141(199804)28:04<1315::AID-IMMU1315>3.0.CO;2-2. View

19.

Stewart-Jones G, di Gleria K, Kollnberger S, McMichael A, Jones E, Bowness P . Crystal structures and KIR3DL1 recognition of three immunodominant viral peptides complexed to HLA-B*2705. Eur J Immunol. 2005; 35(2):341-51. DOI: 10.1002/eji.200425724. View

20.

Mandelboim O, Reyburn H, Vales-Gomez M, Pazmany L, Colonna M, Borsellino G . Protection from lysis by natural killer cells of group 1 and 2 specificity is mediated by residue 80 in human histocompatibility leukocyte antigen C alleles and also occurs with empty major histocompatibility complex molecules. J Exp Med. 1996; 184(3):913-22. PMC: 2192787. DOI: 10.1084/jem.184.3.913. View