Inhibition of Lassa and Marburg Virus Production by Tetherin

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2008 Dec 19

PMID 19091864

Citations 198

Authors

Toshie Sakuma

Takeshi Noda

Shuzo Urata

Yoshihiro Kawaoka

Jiro Yasuda

Affiliations

Soon will be listed here.

Abstract

Recently, tetherin has been identified as an effective cellular factor that prevents the release of human immunodeficiency virus type 1. Here, we show that the production of virus-like particles induced by viral matrix proteins of Lassa virus or Marburg virus was markedly inhibited by tetherin and that N-linked glycosylation of tetherin was dispensable for this antiviral activity. Our data also suggest that viral matrix proteins or one or more components that originate from host cells are targets of tetherin but that viral surface glycoproteins are not. These results suggest that tetherin inhibits the release of a wide variety of enveloped viruses from host cells by a common mechanism.

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